Aryl urea analogs with broad-spectrum antibacterial activity

Design, synthesis and evaluation of some 1,3,5-triazinyl urea and thiourea derivatives as antimicrobial agents

“…The combination the urea derivatives with thiourea lead to inhibitors of DNA topoisomerase [13], antihypertensive activity [14]. Furthermore, the pronounced antimicrobial activity of urea as well as thiourea derivatives [15,16] encouraged us to study the effect of the synthesized compounds against a variety of microorganisms.…”

Antimicrobial and Anti-biofilm Activity of Thiourea Derivatives Incorporating a 2-Aminothiazole Scaffold

“…In our previous studies, 10,11) we reported the synthesis and biological activity of thiourea derivatives. In the recent literature, the thioureas are described as most useful class of agents with large number of activities including antiviral, 12,13) antibacterial 14) and high density lipoprotein (HDL)-elevating properties. 15) Isoxyl (thiocarlide; 4,4′-diisoamyloxydiphenylthiourea)-another example of the thiourea pharmacofore is known to be an effective anti-tuberculosis drug clinically used against a range of multidrug-resistant strains of Mycobacterium tuberculosis.…”

Novel benzothiazolyl urea and thiourea derivatives with potential cytotoxic and antimicrobial activities

“…Ampicillin trihydrate and clotrimazole were used as standard antibacterial and antifungal agents, respectively. Solutions of the test compounds, ampicillin trihydrate and clotrimazole were prepared in DMSO at a concentration of 1600 mg mL 21 . The two-fold dilutions of the compounds were prepared (800, 400,..6.25 mg mL 21 ).…”

“…Solutions of the test compounds, ampicillin trihydrate and clotrimazole were prepared in DMSO at a concentration of 1600 mg mL 21 . The two-fold dilutions of the compounds were prepared (800, 400,..6.25 mg mL 21 ). The microorganism suspensions at 10 6 CFU mL 21 (Colony Forming Unit/mL) concentrations were inoculated to the corresponding wells.…”