Under the background of a new round of scientific and technological revolution and industrial reform, the role of innovation in promoting economic and social development is becoming more and more prominent, which is the key to building regional competitive advantages. Cultural capital can have a sustained and extensive positive impact on regional innovation, which can become an important focus to promoting regional innovation. Using literature studies and case studies, this paper investigated the influence mechanism of cultural capital on regional innovation. The study shows that the cultural capital at the regional level includes the value system shared by the specific regional groups which can promote wealth creation, as well as the cultural activities and its results with utility and value in the specific region. The impact of cultural capital on regional innovation is comprehensive, involving multiple aspects such as innovation subjects, innovation network, innovation input, innovation output and innovation environment. To promote cultural capital conducive to regional innovation, efforts should be made in three aspects of cultural policy: policy objectives, contents and implementation.