Artrose

Flugsrud, Gunnar B; Nordsletten, Lars; Reinholt, Finn P.; Risberg, May Arna; Rydevik, Karin; Uhlig, Till

doi:10.4045/tidsskr.09.1054

Cited by 8 publications

(7 citation statements)

References 55 publications

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“…7,8 Women are more likely to develop either of these conditions than men. 12 RA is more likely caused by genetic and environmental factors. 13 The genetic factors include multiple specific genetic loci, such as Interleukin-6 receptor (IL6R), Tumor necrosis factor receptor-associated factor-1 (TRAF1/C5), Fc gamma receptor (FCGR); polymorphisms, as in the Protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) gene; familial risk among first-degree relatives; racial/ethnic groups at risk, as North American Natives.…”

Section: Rheumatoid Arthritis and Os Teoarthritismentioning

confidence: 99%

Dysbiotic relationship between arthritis and the oral‐gut microbiome. A critical review

Oliveira

Gardev

Shaddox

2022

J of Periodontal Research

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Arthritis and prosthetic joint infections (PJIs) overall are associated with reduced quality of life and limited work capacity. Multiple, overlapping factors contribute to these conditions. Some investigations have suggested a dysbiotic association between the oral‐gut microbiome and pathogenesis of arthritis and PJIs. A better understanding of the role of the oral‐gut microbiota in arthritis and PJI pathophysiology can shed light into how its disequilibrium can discharge a pro‐inflammatory response, and impact the health of patients susceptible to arthritis or with established joint disease. A review of published in vivo and clinical data suggested that alterations in oral and gut microbiota can lead to a disturbance of immunoregulatory properties, and may be associated with joint infections and arthritis. This review brings new insights into the current status of the evidence on the potential molecules and inflammatory biomarkers disrupted by an oral‐gut microbial dysbiosis. Normal commensals and pathogenic oral and gut microflora homeostasis are important not only to prevent infections per se but also its potential progression. Further experiments, especially controlled clinical trials, are needed to ascertain how microbiome manipulation and other microbiota‐directed approaches can help control inflammation and effectively prevent and treat arthritic diseases. Additionally, studies on the effects of the long‐term oral diseases, such as chronic periodontitis, on arthritis and PJIs need to be conducted.

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Section: Rheumatoid Arthritis and Os Teoarthritismentioning

confidence: 99%

Dysbiotic relationship between arthritis and the oral‐gut microbiome. A critical review

Oliveira

Gardev

Shaddox

2022

J of Periodontal Research

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“…The main symptoms are pain, stiffness, joint deformity and cracking (4). Women are more affected by OA than men, and the incidence of OA increases with age (5). So it is considered the most frequent chronic joint disease (6).…”

Section: Introductionmentioning

confidence: 99%

STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway

2019

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Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high incidence and a huge social and economic burden. Therefore, it is urgent to study its potential pathogenesis to improve the therapeutic effect of the disease. In this study, we constructed a number of regulator-mediated OA dysfunction modules, and carried out in-depth analysis in order to examine the disease development process. Differential expression analysis, co-expression analysis and enrichment analysis were combined to screen genes related to disease progression. Subsequently, key regulatory factors in the process of OA were identified based on the pivotal regulators that may manipulate important parts of the module subnetwork. A total of 16 OA dysfunction modules were obtained, involving the aggregation of 3,239 module genes. Then, enrichment analysis showed that module genes were significantly involved in apoptosis, inflammation-related functions and signaling pathways. Finally, we revealed a series of regulators, including 842 ncRNA (miR-132-3p, miR-130a-3p and miR-590-3p), 59 transcription factors (NFKB1, RELA and STAT3). We consider that STAT3 is the core transcription factor and promotes the development of OA through the signal of NF-κB. Overall, our results provide biologists and pharmacists with a new way of thinking to reveal the disease process of OA, and provide a wider range of candidate targets for follow-up research.

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“…O steoarthrosis (OA) is a chronic and degenerative disease that affects synovial joints, including the hip 1 . It is basically characterized by the wear of the cartilage that covers the surfaces of the joint formed by the femoral head and the acetabulum.…”

Section: Introductionmentioning

confidence: 99%

Comparação clínica, laboratorial e densitométrica de pacientes com coxartrose e com fraturas do colo femoral.

Spinelli

Pagnussato

Ribeiro

et al. 2018

Rev. Col. Bras. Cir.

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RESUMO Objetivo: comparar dados clínicos, laboratoriais e densitométricos de pacientes com osteoartrose e com fratura do colo femoral. Métodos: estudo transversal de pacientes com fratura do colo femoral e osteoartrose do quadril, submetidos à artroplastia de quadril. Dados clínicos, laboratoriais e densitométricos foram coletados. Resultados: cinquenta e três pacientes foram incluídos, 22 com fraturas do colo femoral e 31 com osteoartrose. Pacientes com fratura do colo do fêmur apresentaram maior idade do que os pacientes com osteoartrose, tendo valores de IMC, densidade mineral óssea e força de preensão palmar (pacientes sarcopênicos) inferiores, estando mais incapacitados neurologicamente e apresentando um pior escore ASA. Entre os vários parâmetros bioquímicos analisados, diferenças estatisticamente significantes foram encontrados no cálcio sérico total, cálcio ionizado, vitamina D, tiroxina livre, eritrócitos, hemoglobina, hematócrito, glóbulos brancos totais, neutrófilos, linfócitos e creatinina entre os dois grupos. Outros hormônios analisados e parâmetros bioquímicos não diferiram significativamente, apesar de mostrarem tendências entre os dois grupos. Conclusão: pacientes com fraturas do colo do fêmur são mais idosos do que pacientes com osteoartrose, apresentam um menor peso e IMC, são mais debilitados, muitos com anemia e massa óssea reduzida, além de terem uma diminuição significativa no cálcio total, cálcio ionizado, vitamina D e creatinina e um aumento significativo na tiroxina livre.

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Artrose

Abstract: Current treatment options alleviate but do not cure arthritic symptoms; preventive actions should be instigated when possible. Treatment of osteoarthritis involves many medical specialties and treatment modalities.

Cited by 8 publications

References 55 publications

Dysbiotic relationship between arthritis and the oral‐gut microbiome. A critical review

Dysbiotic relationship between arthritis and the oral‐gut microbiome. A critical review

STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway

Comparação clínica, laboratorial e densitométrica de pacientes com coxartrose e com fraturas do colo femoral.

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