Abstract:There is increasing interest in autoimmune diseases, especially their relationship with cardiovascular disease. Rheumatoid arthritis in particular has been considered an independent risk factor for coronary artery disease in recent years. Various studies have aimed to clarify important aspects of risk stratification and treatment options in patients with rheumatoid arthritis, and specific therapies are being studied that promise to reduce their long-term cardiovascular risk. We performed a wide-ranging review … Show more
“…31,32 However, there are also reports describing the so-called “lipid paradox” in inflammatory diseases, mainly rheumatoid arthritis, marked by a significant decrease in LDL-cholesterol and TC levels 3-5 years before the onset of signs of the disease. 34,35 There also evidences of possible influence of pharmacological interventions on lipid profile of these patients. 36…”
BackgroundPsoriasis correlates with metabolic disorders, early atheromatosis and
increased cardiovascular risk.ObjectivesTo assess markers of cardiovascular disease in psoriatic patients.MethodsCross-sectional, observational study involving 11 psoriatic participants and
33 controls. Anthropometric, biochemical, hemodynamic and imaging parameters
were evaluated. Arterial stiffness was assessed by oscillometric measurement
of the brachial artery. Intima-media thickness (IMT) and left ventricular
diastolic function were assessed by Doppler echography and echocardiography.
Between-group comparisons of numerical variables were performed by the
Student’s t-test or Wilcoxon Mann-Whitney test for independent samples.
Significance level was set at 5%.ResultsPsoriatic patients showed increased pulse wave velocity (PWV) (9.1 ±
1.8 vs 8.0 ± 2 m/s, p = 0.033), IMT of the left common carotid artery
(p = 0.018) and a higher percentage of patients above the 75th
percentile according to the ELSA table when compared with controls (54.5 vs
18.2%, p = 0.045). Psoriatic patients also showed an increase in
peripheral/central systolic blood pressure (137.1 ± 13.2 vs 122.3
± 11.6 mmHg, p = 0.004)/(127 ± 13 vs 112.5 ± 10.4 mmHg,
p = 0.005), peripheral/central diastolic blood pressure (89.9 ± 8.9
vs 82.2 ± 8, p = 0.022)/(91 ± 9.3 vs 82.2 ± 8.3, p =
0.014), total cholesterol (252 ± 43.5 vs 198 ± 39.8 mg/dL, p
< 0.001), LDL cholesterol (167 ± 24 vs 118 ± 40.8 mg/dL, p
< 0.001) and C-reactive protein (7.6 ± 35.4 vs 1 ± 1.2 mg/L
p < 0.001) compared with controls.ConclusionPsoriasis patients show increased PWV, IMT, peripheral and central blood
pressures, and serum cholesterol and C-reactive protein levels, denoting a
higher cardiovascular risk.
“…31,32 However, there are also reports describing the so-called “lipid paradox” in inflammatory diseases, mainly rheumatoid arthritis, marked by a significant decrease in LDL-cholesterol and TC levels 3-5 years before the onset of signs of the disease. 34,35 There also evidences of possible influence of pharmacological interventions on lipid profile of these patients. 36…”
BackgroundPsoriasis correlates with metabolic disorders, early atheromatosis and
increased cardiovascular risk.ObjectivesTo assess markers of cardiovascular disease in psoriatic patients.MethodsCross-sectional, observational study involving 11 psoriatic participants and
33 controls. Anthropometric, biochemical, hemodynamic and imaging parameters
were evaluated. Arterial stiffness was assessed by oscillometric measurement
of the brachial artery. Intima-media thickness (IMT) and left ventricular
diastolic function were assessed by Doppler echography and echocardiography.
Between-group comparisons of numerical variables were performed by the
Student’s t-test or Wilcoxon Mann-Whitney test for independent samples.
Significance level was set at 5%.ResultsPsoriatic patients showed increased pulse wave velocity (PWV) (9.1 ±
1.8 vs 8.0 ± 2 m/s, p = 0.033), IMT of the left common carotid artery
(p = 0.018) and a higher percentage of patients above the 75th
percentile according to the ELSA table when compared with controls (54.5 vs
18.2%, p = 0.045). Psoriatic patients also showed an increase in
peripheral/central systolic blood pressure (137.1 ± 13.2 vs 122.3
± 11.6 mmHg, p = 0.004)/(127 ± 13 vs 112.5 ± 10.4 mmHg,
p = 0.005), peripheral/central diastolic blood pressure (89.9 ± 8.9
vs 82.2 ± 8, p = 0.022)/(91 ± 9.3 vs 82.2 ± 8.3, p =
0.014), total cholesterol (252 ± 43.5 vs 198 ± 39.8 mg/dL, p
< 0.001), LDL cholesterol (167 ± 24 vs 118 ± 40.8 mg/dL, p
< 0.001) and C-reactive protein (7.6 ± 35.4 vs 1 ± 1.2 mg/L
p < 0.001) compared with controls.ConclusionPsoriasis patients show increased PWV, IMT, peripheral and central blood
pressures, and serum cholesterol and C-reactive protein levels, denoting a
higher cardiovascular risk.
Serum OPG levels were increased and correlated with CIMT and PWV in RA patients. In addition to PWV and CIMT, OPG may be a useful biomarker for CV risk management in RA patients.
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