Artocarpus nigrifolius: Cytotoxic and antibacterial constituents

Hoi, Tran Minh; Anh, Ha Van; Hương, Nguyễn Thị Thanh; Tuyen, Nguyen Van; Anh, Le Thị Tu; Tra, Nguyen Thanh; Cham, Ba Thi; Hà, Nguyễn Thị Thu; Long, Pham Duy; Tien, Doan Duy; Kiệm, Phan Văn; Ban, Ninh Khac; Kukhareva, L. V.; Tatiana, Gill; Kim, Young Ho

doi:10.1007/s13765-013-3259-6

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Caffeic acid derivatives can be found in PNE. Previous reports show that friedelin, sitosterol, some fatty acids and phenolic acids present cytotoxicity to several strains (Begin et al, 1988;Hoi et al, 2013;Matos et al, 2006;Ozcelik et al, 2011;Thao et al, 2010;Velasquez et al, 1993). Therefore, the presence of those compounds might explain the cytotoxicity observed.…”

Section: Resultsmentioning

confidence: 92%

Cytotoxic effect of Plectranthus neochilus extracts in head and neck carcinoma cell lines

Borges¹,

Ferreira²,

Elias³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Following a tendency of studying the potential effects of plant extracts to cancer, this study aimed to evaluate in vitro the cytotoxic activity of Plectranthus neochilus (PN) extracts and its fractions in head and neck squamous cell carcinoma (HNSCC) cell lines and assess their tumor specificity. MTT assay was conducted with two HNSCC cell lines, FaDu (hypopharynx carcinoma) and SCC-25 (tongue carcinoma), one keratinocyte (HaCat) and one fibroblast (L929) cell line. Two PN leaf crude extracts, one ethanolic (E) and one hexanic (H), and their nine fractions were tested. A dose-response curve was performed with hexane PNH fraction and a tumor specificity index (TSI) was calculated. For all cell lines studied, almost all extracts and fractions resulted in cell viability lower than 50%. Hexane and methanol PNH fractions were exceptions, causing a significantly low viability in SCC-25 (17.16 and 34.53%, respectively), but higher than 50% in FaDu, HaCat and L929. The dose-response curve with hexane PNH fraction resulted in a CC 50 of 540.9 µg/mL for FaDu, 550 µg/mL for L929, 762.1 µg/mL for HaCat and 274.2 µg/mL for SCC-25. The TSI L929/FaDu was 1.01, HaCat/FaDu was 1.40, L929/SCC-25 was 2.00 and HaCat/SCC-25 was 2.77. TSIs indicate its specificity for tongue carcinoma cells, when compared to fibroblasts and keratinocytes.

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Section: Resultsmentioning

confidence: 92%

Cytotoxic effect of Plectranthus neochilus extracts in head and neck carcinoma cell lines

Borges¹,

Ferreira²,

Elias³

et al. 2016

Afr. J. Pharm. Pharmacol.

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“…Some plants of this genus are used as traditional folk medicines in Indonesia [2], India [3], Cameroon [4], and China [5]. The previous studies on the plants of this genus led a series of isoprenylated flavonoids and stilbenoids [6,7], some of which possessed cytotoxicity [8] and tyrosinase inhibitory effects [9], and antibacterial [10] and antiinflammatory activities [11].…”

Section: Introductionmentioning

confidence: 99%

Novel stilbenes fromArtocarpus nanchuanensis

Zhang

2015

Journal of Asian Natural Products Research

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Four new stilbene derivatives, hypargystilbenes B-E (1-4), together with seven known compounds (5-11), were isolated from the stems of Artocarpus nanchuanensis S.S. Chang. Their structures were elucidated on the basis of spectral data. Hypargystilbene B, hypargystilbene D, and hypargystilbene E exhibited protein tyrosine phosphatase 1B inhibitory effects with corresponding IC50 values of 3.23, 37.31, and 2.53 nM.

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