Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus

Aujard, Fabienne; Dkhissi-Benyahya, Ouria; Fournier, Isabelle; Bruno, Claudio; Schilling, Alain; Cooper, H.M; Perret, Martine

doi:10.1016/s0306-4522(01)00202-0

Cited by 54 publications

(46 citation statements)

References 42 publications

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“…exposure may decrease with age (Zhang et al, 1996;Benloucif et al, 1997;Aujard et al, 2001). Taken together, these data suggest that age could have profound effects on the synchronization of circadian rhythms to changes in daylength.…”

Section: Introductionmentioning

confidence: 75%

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Aujard

Cayetanot

Terrien

et al. 2007

Experimental Gerontology

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To cite this version:Fabienne Aujard, Florence Cayetanot, Jérémy Terrien, Eus J.W. Van Someren. Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate. Experimental Gerontology, Elsevier, 2007, 42 (11) ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ABSTRACTAdaptation of physiological and behavioral functions to seasonal changes in daylength is of major relevance for optimal fitness and survival. Because aging is characterized by changes in biological rhythms, it may be hypothesized that old animals fall short of showing a full adaptation to prolonged changes in the duration of daily light exposure, as naturally occurring in relation to season in younger individuals. To test this hypothesis, we analyzed changes in the patterns of daily locomotor activity and body temperature rhythms of young and old mouse lemurs (Microcebus murinus, Primates) exposed to short and long daylengths. The effect of an increase in the duration of daily light exposure was attenuated in old animals, as compared to younger lemurs. Although some age-related differences in the locomotor activity rhythm could be seen under exposure to short daylength, they were predominant under long daylength. Some mechanisms allowing adaptation to changing day length thus seem to be impaired at old age. Changes in coupling of circadian oscillators to the light-dark cycle and disturbances in the physiological responses to change in light duration should be further investigated.

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Section: Introductionmentioning

confidence: 75%

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Aujard

Cayetanot

Terrien

et al. 2007

Experimental Gerontology

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“…Such photoperiodic changes and abnormalities have been associated with mortality in mammalian species 39 Fifth, long sleep (or even long time in bed) may be associated with a lack of physiological challenge. A number of stressors, such as exercise, irradiation, heat and cold shock, and hypergravity, have been linked to longevity in many species, when compared to a relative absence of these stressors 40 .…”

Section: Possible Causes Of Mortality In Long Sleepmentioning

confidence: 99%

Who are the long sleepers? Towards an understanding of the mortality relationship

Grandner

Drummond

2007

Sleep Medicine Reviews

353

295

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While much is known about the negative health implications of insufficient sleep, relatively little is known about risks associated with excessive sleep. However, epidemiological studies have repeatedly found a mortality risk associated with reported habitual long sleep. This paper will summarize and describe the numerous studies demonstrating increased mortality risk associated with long sleep. Although these studies establish a mortality link, they do not sufficiently explain why such a relationship might occur. Possible mechanisms for this relationship will be proposed and described, including (1)sleep fragmentation, (2)fatigue, (3)immune function, (4)photoperiodic abnormalities, (5)lack of challenge, (6)depression, or (7)underlying disease process such as (a)sleep apnea, (b)heart disease, or (c)failing health. Following this, we will take a step back and carefully consider all of the historical and current literature regarding long sleep, to determine whether the scientific evidence supports these proposed mechanisms and ascertain what future research directions may clarify or test these hypotheses regarding the relationship between long sleep and mortality. WHO ARE THE LONG SLEEPERS?How much sleep do we need?Whereas the answer to this question usually involves the determination of the minimum amount of sleep required for the maintenance of health, less attention has been directed to the question of the maximum amount of sleep for optimum health. This may be an equally important issue, given research suggesting that there are negative health consequences of excessive sleep 1 .There is growing public awareness of the need for an adequate amount of sleep, and the myriad problems associated with insufficient sleep, which is consistent with a hypothesis

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“…The mean life span of the prosimian primate Microcebus murinus is decreased 28% by an accelerated photoperiodic regimen [115]. Moreover, a shortened diurnal cycle is associated with diminished nocturnal melatonin secretion [116] and can hasten the appearance of several behavioral deficits associated with aging [117]. It is interesting that the extreme longevity of healthy centenarians is associated with a pronounced diurnal flux of melatonin [118].…”

Section: The Link Between Aging and Circadian Eventsmentioning

confidence: 99%

Melatonin, Oxidative Stress, and the Aging Brain

Bondy

Sharman

2010

Aging and Age-Related Disorders

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The changes associated with brain aging are discussed with emphasis on altered oxidative and inflammatory events and on mitochondrial dysfunction. Many of these changes are exacerbated in a variety of age-related neurologic diseases. This commonality has led to the idea that similar therapeutic approaches may be used in the treatment of several apparently unrelated neurodegenerative disorders. When aspects of these diseases are modeled in experimental animals and cell lines, the application of melatonin has been reported to be advantageous. The means by which melatonin can be protective probably is mediated by way of activation of melatonin receptors, of which several subtypes can be identified. This can initiate a sequence of intracellular signaling events and by activation of transcription factors lead to altered gene expression. The culmination of this cascade can lead to increased levels of antioxidant enzymes and depressed levels of inflammation. Melatonin may be useful both in the retardation of nonpathologic brain aging and in the amelioration of chronic brain disease associated with aging. The inexpensive nature and ready availability of melatonin together with its very low toxicity reinforce the need to place the beneficial properties of this agent on a firmer basis.

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Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus

Cited by 54 publications

References 42 publications

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Who are the long sleepers? Towards an understanding of the mortality relationship

Melatonin, Oxidative Stress, and the Aging Brain

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