Artificial Reproductive Technology – A Risk Factor for Retinopathy of Prematurity

Trifonova, K.; Slaveykov, Kiril; Mumdzhiev, Hristo; Dzhelebov, Dimitar

doi:10.3889/oamjms.2018.448

Cited by 12 publications

(15 citation statements)

References 25 publications

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“…In 2018, Trifonova et al have published a systematic review to discuss the relationship between ART and ROP. Consistent with our findings, the results showed that though insignificant, ROP was observed which more frequently happened in ART [18]. As this systematic review only included studies directly comparing ROP happened in ART and SC groups, the observational studies which contained the data of ROP when comparing the birth defects between ART and SC could be omitted.…”

Section: Discussionsupporting

confidence: 82%

“…Simultaneously, Chiarelli et al discovered that though statistically insignificant, ART still presented higher ROP occurrence than spontaneous conception (SC) [17]. In 2018, Trifonova et al had conducted a systematic review about studies regarding ART as an independent risk factor for ROP [18]. Results showed no significant relationship of ART and stage 3 ROP and no further meta-analysis had been performed.…”

Section: Introductionmentioning

confidence: 99%

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The Risk of Retinopathy of Prematurity in the Infants following Assisted Reproductive Technology: A Meta-Analysis

Gao

Shao

et al. 2019

BioMed Research International

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Currently, the use of assisted reproductive technology (ART) is increasing. Because of the poor prognosis of retinopathy of prematurity (ROP), the association between ART and the ROP has been explored in several studies, but the result was still inconclusive. Conducting a meta-analysis, we evaluated the risk of ROP in relation to the ART. Subgroup analysis as well as groups with different embryo numbers and different ROP stages was further analyzed. The PubMed, Embase, and Cochrane Library databases were searched for studies recording data about both the use of ART and ROP occurrence simultaneously. Odds ratios (ORs) and 95% confidence interval (95%CI) were calculated to analyze the association by using random- or fixed-effect models based on heterogeneity test. In total 15 observational studies containing 10392 ART cases and 39474 spontaneous conception cases were included. Results showed that there was a significant association between the use of ART and ROP occurrence in the offspring (OR = 1.34, 95% CI: 1.05 to 1.73, P = 0.02). With subgroup analysis, we found that the influence actually came from a subgroup of ART, the in vitro fertilization (IVF). Moreover, there was a significant association between ART and ROP in singletons. Though insignificant, the ORs were larger than 1 in the analysis between ART and stage 1 and 2 ROP. But ART showed significant association with stage 3 ROP. Our study preliminarily indicated that the use of IVF was associated with higher risk of ROP occurrence. And ART is more likely to result in severe ROP and ROP in singletons. Further specific, high-quality studies with large sample size are still needed to draw more precise conclusion.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

The Risk of Retinopathy of Prematurity in the Infants following Assisted Reproductive Technology: A Meta-Analysis

Gao

Shao

et al. 2019

BioMed Research International

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“…Studies have reported inconsistent results regarding this relationship. 5 The incidence of ROP in the literature from Saudi Arabia varies from 23.31% to 46.4%. 6,7 Because of the improvements in neonatal care, the incidence has been increasing in the last few years, and hence, the survival of extremely premature babies increased.…”

Section: Introductionmentioning

confidence: 99%

Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?

Alsammahi

Basheikh

2021

OPTH

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This study aimed to determine the incidence of retinopathy of prematurity (ROP) and to assess whether assisted reproductive technology (ART) is a risk factor for ROP independent of the generation of multiple births by determining the occurrence and severity of ROP and the need for treatment. We will also evaluate other risk factors associated with the development of ROP among preterm infants. Patients and Methods: We conducted a retrospective chart review for all premature infants who were screened for ROP according to the screening guidelines of the American Academy of Ophthalmology and born at King Abdulaziz University Hospital from 2015 to 2019. In addition to ophthalmological results, data on gestational age (GA), birth weight (BW), type of pregnancy (singleton or multiple), type of conception (natural or ART), infantile factors, and maternal factors were recorded. Results: A total of 229 preterm babies met our criteria. The mean GA at birth was 29.35 weeks. Notably, 175 neonates were conceived naturally and 54 were conceived by ART. Furthermore, 33 infants in the natural conception group were products of multiple pregnancies, as were 49 infants in the ART group. ROP was noted in 96 of 229 infants (41.92%). No significant difference was found in the occurrence of ROP between multiple neonates in the natural and ART groups. However, ART birth babies in general were significantly associated with the development of ROP (P=0.045). On multiple regression analysis, early GA, low BW, and extended oxygen therapy were the variables most significantly associated with ROP (P≤0.001). Conclusion:In our sample, ART in multiple birth babies per se did not seem to be a risk factor for ROP. However, ART babies were more prone to develop ROP than natural conception birth babies, which seemed to be more severe.

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“…Also, unlike our study, the study by Corchia et al [16] has shown that there is no significant difference in the incidence of ROP between prematurely born newborns conceived with ART and those who were spontaneously conceived. By contrast, other studies found an increased incidence of both BPD and ROP in babies who were conceived by IVF [15,17].…”

Section: Discussionmentioning

confidence: 77%

Characteristics and morbidity of prematurely born newborns conceived with assisted reproductive technologies

et al. 2020

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Introduction/Objective. The proportion of live-born infants conceived with assisted reproductive technologies (ART) in some European countries reaches 6% and in Serbia over 1%. The aim of this study was to analyze characteristics and morbidity of prematurely born newborns conceived with ART. Methods. The study included 154 prematurely born newborns from pregnancies conceived with ART and 154 prematurely born newborns conceived naturally hospitalized at the Institute of Health Care of Children and Adolescents of Vojvodina. Participants from both groups were matched according to gestational age and date of birth. Results. Statistically significantly more newborns with very low birth weight have been in group of newborns conceived by ART in comparison to newborns conceived naturally (?2 test, p = 0.0002). Morbidity of newborns conceived with ART is not higher in comparison to newborns of the same gestational age conceived naturally. Bronchopulmonary dysplasia, occurred more frequently in children from ART (?2 test, p = 0.006) and retinopathy of prematurity, occurred more frequently in children spontaneously conceived. (?2 test, p = 0.047). There was no difference in the frequency of birth defects, genetic syndromes and inborn errors of metabolism between two groups. Conclusion. Lower birth weight and intrauterine growth restriction are potential risk factors for worse postnatal outcome in newborns from pregnancies conceived with ART.

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Artificial Reproductive Technology – A Risk Factor for Retinopathy of Prematurity

Cited by 12 publications

References 25 publications

The Risk of Retinopathy of Prematurity in the Infants following Assisted Reproductive Technology: A Meta-Analysis

The Risk of Retinopathy of Prematurity in the Infants following Assisted Reproductive Technology: A Meta-Analysis

Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?

Characteristics and morbidity of prematurely born newborns conceived with assisted reproductive technologies

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