Artificial peptides binding to the c face of hydroxyapatite obtained by molecular display technology

Ono, Shohei; Oaki, Yuya; Imai, Hiroaki

doi:10.1039/c2ra22382a

Cited by 2 publications

(1 citation statement)

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“…4 An artificial linear peptide (NPPTRQTKPKRVANTN) binding to the c face of HA was obtained using the mRNA display method. 5 The results of this study suggest that the amino acid sequence including Ala-Asn-Thr (ANT) is essential for binding specificity. The crystal growth of HA was found to be modulated by particular peptides.…”

Section: Introductionmentioning

confidence: 89%

Fabrication of self-standing films consisting of enamel-like oriented nanorods using artificial peptide

et al. 2015

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We achieved the fabrication of enamel-like films consisting of c-axis-oriented hydroxyapatite (HA) nanorods by a two-step controlled crystal growth method with the monolayer of a specific artificial peptide binding to the c face of HA. Self-standing films were formed under the monolayer at the air-water interface in an aqueous solution system that was based on a simulated body fluid. The presence of fluoride ions promoted the arrangement of apatite microrods in the c direction through geometric selection. The subsequent growth with aspartic acid produced the enamel-like structure consisting of c-axis-oriented nanorods on the basal microrods. Therefore, the controlled crystal growth using the aqueous system including the specific artificial peptide, fluoride ion, and aspartic acid is regarded as a novel fabrication route for wellorganized architectures.

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Section: Introductionmentioning

confidence: 89%