“…The required performance insuring good reliability, robustness, and accuracy could not be accomplished owing to insulin action, the delay between glucose detection, and non-variable gain factors. Some of the optimal control techniques to deal with glucose monitoring issues include Fuzzy control [7,8], FOPIDC/JAYA control [9]; GA-PIC control [10]; Sliding Mode (SM) control [11][12][13][14], Linear Quadratic Gaussian (LQG) control [15] , H∞ control [16][17][18], MPC/LF control [19] and Model Predictive (MP) control [20,22]. In comparison to PID controllers, glucose monitoring in patients within the normo-glycaemia range using the above mentioned controllers improved the performance to some extent.…”