Artificial nerve graft using glycolide trimethylene carbonate as a nerve conduit filled with collagen compared to sutured autograft in a rat model

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

“…As mentioned in Section 2, the natural ECM, consisting of various proteins (collagen, laminin, fibronectin) and polysaccharides, significantly affects neural regeneration [179]. Through the interaction with its ECM, cell activity is regulated for morphogenesis, maintenance, and adaptation purposes [180].…”

“…Collagen is known to promote cell proliferation, possess good affinity with the living body, generate minimum scar tissue, and cause little inflammatory response or immunological reaction [181,182]. Rosen et al used a biodegradable and flexible conduit made of glycolide trimethylene carbonate (GTMC) filled with a collagen matrix to bridge a relatively short nerve gap of 5 mm of a rat peroneal nerve, and concluded that the outcome from the artificial conduit was similar to the one from autografts in terms of organization and reaction at the graft site, quantitative physiology, axon diameter and toe spread analysis [179]. However, statistically, the axon count in the autografts was significantly higher than inthe artificial conduit [179].…”

“…Rosen et al used a biodegradable and flexible conduit made of glycolide trimethylene carbonate (GTMC) filled with a collagen matrix to bridge a relatively short nerve gap of 5 mm of a rat peroneal nerve, and concluded that the outcome from the artificial conduit was similar to the one from autografts in terms of organization and reaction at the graft site, quantitative physiology, axon diameter and toe spread analysis [179]. However, statistically, the axon count in the autografts was significantly higher than inthe artificial conduit [179]. Clinically, the peripheral nerve injury gap is usually larger than 5 mm; therefore, research on bridging a wider gap would provide more useful information.…”

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

“…Collagen is the major constituent of all extracellular matrices. There are at least 15 different types of collagen in vertebrates (Linsenmayer, 1991) among which type I (fibrillar), type II (fibrillar), type III (fibrillar), and type IV (network forming: nonfibrillar) collagen have been used as extracellular matrices to study their effects on growth of regenerating nerves (Satou et al, 1986;Madison et al, 1988;Rosen et al, 1992). The amnion membrane that is found in the placentae containing molecules of laminin and collagen has been used as a substratum for cultured neuronal cells (Danielsen et al, 1988).…”

“…Biodegradable materials, such as polyester homopolymers or copolymers of glycolic acid and lactic acid, or polymers of dicarboxylic acids and diols, have been successfully used in experimental studies of nerve tubulization (Nyilas et al, 1983;Rosen et al, 1992). In these studies, it showed that the biodegradable tubes were resorbed by the body soon after axons penetrated the distal stump.…”