Artificial nerve conduits in peripheral‐nerve repair

Kannan, Ruben Y.; Salacinski, Henryk J.; Butler, Peter E. M.; Seifalian, Alexander M.

doi:10.1042/ba20040137

Cited by 59 publications

(4 citation statements)

References 88 publications

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“…The stent-graft was made using a 30-mm collapsible stainless steel scaffold dip-coated with the previously described POSS-PCU polymer. 9 To promote a homogenous coating, a low viscosity or thin polymer formulation was developed by adding additional dimethylacetamide (DMAC) to a 20 wt% polymer solution, which was rested overnight to ensure that the DMAC was fully dissolved. Nitinol wire with shape-memory properties was constrained between pins in a rig to make Z stents, which were then wrapped around a cylinder tube, heated in an oven at 550°C for 15 minutes, and air cooled.…”

Section: Methodsmentioning

confidence: 99%

A Sutureless Aortic Stent-Graft Based on a Nitinol Scaffold Bonded to a Compliant Nanocomposite Polymer Is Durable for 10 Years in a Simulated In Vitro Model

Desai

Bakhshi

Xiang

et al. 2012

Journal of Endovascular Therapy

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Section: Methodsmentioning

confidence: 99%

A Sutureless Aortic Stent-Graft Based on a Nitinol Scaffold Bonded to a Compliant Nanocomposite Polymer Is Durable for 10 Years in a Simulated In Vitro Model

Desai

Bakhshi

Xiang

et al. 2012

Journal of Endovascular Therapy

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“…But in the clinical setting, many patients complained of irritation at the site of surgery, which required subsequent removal. Therefore, the method has become clinically unpopular [ 61 ]. Polytetrafluoroethylene (PTFE) was introduced as a polymer for spanning gaps of up to 40 mm, but, over time, it was found to compress the nerve, leading to altered nerve regeneration as well as causing irritation to the patient.…”

Section: Commercialized Guidance Conduits and Wraps For Pnimentioning

confidence: 99%

Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules

Tian

Prabhakaran

Ramakrishna

2015

Regenerative Biomaterials

148

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Nerve diseases including acute injury such as peripheral nerve injury (PNI), spinal cord injury (SCI) and traumatic brain injury (TBI), and chronic disease like neurodegeneration disease can cause various function disorders of nervous system, such as those relating to memory and voluntary movement. These nerve diseases produce great burden for individual families and the society, for which a lot of efforts have been made. Axonal pathways represent a unidirectional and aligned architecture allowing systematic axonal development within the tissue. Following a traumatic injury, the intricate architecture suffers disruption leading to inhibition of growth and loss of guidance. Due to limited capacity of the body to regenerate axonal pathways, it is desirable to have biomimetic approach that has the capacity to graft a bridge across the lesion while providing optimal mechanical and biochemical cues for tissue regeneration. And for central nervous system injury, one more extra precondition is compulsory: creating a less inhibitory surrounding for axonal growth. Electrospinning is a cost-effective and straightforward technique to fabricate extracellular matrix (ECM)-like nanofibrous structures, with various fibrous forms such as random fibers, aligned fibers, 3D fibrous scaffold and core-shell fibers from a variety of polymers. The diversity and versatility of electrospinning technique, together with functionalizing cues such as neurotrophins, ECM-based proteins and conductive polymers, have gained considerable success for the nerve tissue applications. We are convinced that in the future the stem cell therapy with the support of functionalized electrospun nerve scaffolds could be a promising therapy to cure nerve diseases.

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“…We have developed a range of nanocomposite polymers composed of polyhedral oligomeric silsesquioxane (POSS) nanocage structures incorporated in to poly(carbonate‐urea)urethane (POSS‐PCU)92 with both mechanical and surface properties similar to the native vessels 93–95. The nanocomposites have anti‐thrombogenic biomimetic surface properties, and have been extensively tested in vivo in ovine models and have been shown to enhance in situ endothelialization 96, 97.…”

Section: Nanomaterials As Delivery Vehicles For Nomentioning

confidence: 99%

Nitric Oxide Donors for Cardiovascular Implant Applications

Naghavi

Mel

Alavijeh

et al. 2012

Small

160

123

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In an era of increased cardiovascular disease burden in the ageing population, there is great demand for devices that come in to contact with the blood such as heart valves, stents, and bypass grafts that offer life saving treatments. Nitric oxide (NO) elution from healthy endothelial tissue that lines the vessels maintains haemostasis throughout the vasculature. Surgical devices that release NO are desirable treatment options and N-diazeniumdiolates and S-nitrosothiols are recognized as preferred donor molecules. There is a keen interest to investigate newer methods by which NO donors can be retained within biomaterials so that their release and kinetic profiles can be optimized. A range of polymeric scaffolds incorporating microparticles and nanomaterials are presenting solutions to current challenges, and have been investigated in a range of clinical applications. This review outlines the application of NO donors for cardiovascular therapy using biomaterials that release NO locally to prevent thrombosis and intimal hyperplasia (IH) and enhance endothelialization in the fabrication of next generation cardiovascular device technology.

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Artificial nerve conduits in peripheral‐nerve repair

Cited by 59 publications

References 88 publications

A Sutureless Aortic Stent-Graft Based on a Nitinol Scaffold Bonded to a Compliant Nanocomposite Polymer Is Durable for 10 Years in a Simulated In Vitro Model

A Sutureless Aortic Stent-Graft Based on a Nitinol Scaffold Bonded to a Compliant Nanocomposite Polymer Is Durable for 10 Years in a Simulated In Vitro Model

Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules

Nitric Oxide Donors for Cardiovascular Implant Applications

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