Artificial nano-red blood cells nanoplatform with lysosomal escape capability for ultrasound imaging-guided on-demand pain management

Qiao, Bin; Song, Xinye; Zhang, Nan; Xu, Ming; Zhuang, Bowen; Guo, Huanling; Wu, Wenxin; Yang, Zhuyang; Xie, Xiaoyan; Luan, Yihui; Zhang, Chunyang

doi:10.1016/j.actbio.2023.01.004

Cited by 4 publications

(3 citation statements)

References 59 publications

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“…Furthermore, nanoparticles can be used to detect the source of pain signals. The injection of nanoparticles locally into the pain site may help to accurately identify the source of pain molecules by localising and tracking neurotransmitter secretion in vivo ( Tronino et al, 2016 ; Khanna et al, 2021 ; Qiao et al, 2023 ). This approach enables the precise targeting of pain treatment, representing the latest advancements in nanotechnology in this field.…”

Section: Discussionmentioning

confidence: 99%

Global research trends of nanotechnology for pain management

Zhu,

Yao,

Kuang

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Nanotechnology has been increasingly used in healthcare during recent years. However, the systematic evaluation of research on nanotechnology for pain management is lacking. In this study, we employed a bibliometric approach to examine the status of the research and global trends of nanotechnology in relation to pain management.Methods: We selected relevant papers published in the Web of Science Core Collection database between 2013 and 2022 using search terms related to nanotechnology and pain management. Subsequently, the following bibliographic information was collected: publication year, originating country/region, affiliated authors and institutions, published journal, references cited, citation frequency, and keywords. The bibliometric software programs VOSViewer and CiteSpace were employed to obtain bibliometric statistics and perform visual analysis.Results: A total of 2680 papers were retrieved. The number of publications in the field of nanotechnology for pain management has been increasing annually since 2013. China had the highest number of published papers, whereas the United States led in total citations. The Chinese Academy of Sciences was the most prolific institution, while the Tehran University of Medical Sciences had the highest overall citations. Furthermore, De Paula was the most prolific author. Papers associated with nanotechnology for pain management were mainly published in the International Journal of Pharmaceutics, Pharmaceutics, and the International Journal of Nanomedicine. Keyword analysis showed that “in-vitro” and “drug-delivery” appeared most frequently, with the top 10 common keywords comprising nanoparticles, pain, in-vitro, drug-delivery, delivery, release, inflammation, neuropathic pain, formulation, and expression. Lastly, the latest emerging keyword was “electrochemical sensor”.Conclusion: Research on applying nanotechnology for pain management is growing steadily. China is the top country in terms of number of publications, with institutions under the Chinese Academy of Sciences making significant contributions to this field. “In-vitro” and “drug-delivery” are the current hotspots in this area, with “electrochemical sensor” as the latest topic at the research forefront. However, national and inter-institutional collaborations should be strengthened to enable patients with pain disorders to benefit from nanotechnology implementation in pain management.

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Section: Discussionmentioning

confidence: 99%

Global research trends of nanotechnology for pain management

Zhu,

Yao,

Kuang

et al. 2023

Front. Bioeng. Biotechnol.

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“…Repeated freeze-thaw cycles or hypotonic incubation can be used to perform cell lysis, followed by the isolation of the cytoplasmic membrane by centrifugation. 33,99,112 The isolation and extraction of CMs from nucleated cells is a more complex process. First, cells need to be screened based on markers on the CM surface.…”

Section: The Fabrication Of Biomimetic Nanoparticlesmentioning

confidence: 99%

How Nanotherapeutic Platforms Play a Key Role in Glioma? A Comprehensive Review of Literature

Yang¹,

Cheng²,

Luo³

et al. 2023

IJN

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Glioblastoma (GBM), a highly aggressive form of brain cancer, is considered one of the deadliest cancers, and even with the most advanced medical treatments, most affected patients have a poor prognosis. However, recent advances in nanotechnology offer promising avenues for the development of versatile therapeutic and diagnostic nanoplatforms that can deliver drugs to brain tumor sites through the blood-brain barrier (BBB). Despite these breakthroughs, the use of nanoplatforms in GBM therapy has been a subject of great controversy due to concerns over the biosafety of these nanoplatforms. In recent years, biomimetic nanoplatforms have gained unprecedented attention in the biomedical field. With advantages such as extended circulation times, and improved immune evasion and active targeting compared to conventional nanosystems, bionanoparticles have shown great potential for use in biomedical applications. In this prospective article, we endeavor to comprehensively review the application of bionanomaterials in the treatment of glioma, focusing on the rational design of multifunctional nanoplatforms to facilitate BBB infiltration, promote efficient accumulation in the tumor, enable precise tumor imaging, and achieve remarkable tumor suppression. Furthermore, we discuss the challenges and future trends in this field. Through careful design and optimization of nanoplatforms, researchers are paving the way toward safer and more effective therapies for GBM patients. The development of biomimetic nanoplatform applications for glioma therapy is a promising avenue for precision medicine, which could ultimately improve patient outcomes and quality of life.

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“…This involved incorporating levobupivacaine and perfluoropentane into dendritic mesoporous silica and covering them with red blood cell membranes to prolong pain relief in living organisms. These collective efforts represent significant strides in the advancement of artificial blood products and their potential clinical applications [7]. This project intends to artificially synthesize red blood cells through the following steps: Ficoll blood purification, polyformaldehyde fixation of red blood cells, extraction and measurement of hemoglobin, mineralization and enhanced mineralization of hemoglobin, gradient dehydration using anhydrous ethanol and HMDS, and construction of sodium alginate and chitosan structures on hemoglobin.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and use of red blood cells

2024

medbm

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Red blood cells and their functions are indispensable for the human body, many medical institutions are more or less facing the problem of blood supply shortage, red blood cells themselves are difficult to store, once removed from the human body, the shelf life is very short. This project is mainly to conduct research and exploration through scientific research experiments, which are also interspersed with some data inquiries. In this study, artificial red blood cells with normal physiological function were successfully obtained. The significance of this research is that it can help solve the problem of shortage of blood source and difficult storage of red blood cells. The successful synthesis of red blood cells helps to extend the storage time of red blood cells, reduce unnecessary blood waste, and further promote the in-depth understanding of human red blood cells.

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Artificial nano-red blood cells nanoplatform with lysosomal escape capability for ultrasound imaging-guided on-demand pain management

Cited by 4 publications

References 59 publications

Global research trends of nanotechnology for pain management

Global research trends of nanotechnology for pain management

How Nanotherapeutic Platforms Play a Key Role in Glioma? A Comprehensive Review of Literature

Synthesis and use of red blood cells

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