Artificial Liver Bioreactor Design

Zeilinger, Katrin; Gerlach, Jörg C.

doi:10.1002/9783527683369.ch5

Bioreactors 2016

DOI: 10.1002/9783527683369.ch5

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Artificial Liver Bioreactor Design

Katrin Zeilinger

Jörg C. Gerlach

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2017

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“…Bioartificial liver (BAL) devices are based on the inclusion of a biological component like primary liver cells to replace to a large extent some of the major synthetic functions of the liver71415. However, a purely biological device may not achieve synthetic and detoxification functions to its full potential2.…”

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confidence: 99%

Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support

Damania

Hassan

Shirakigawa

et al. 2017

Sci Rep

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Conventionally, some bioartificial liver devices are used with separate plasmapheresis unit to separate out plasma from whole blood and adsorbent column to detoxify plasma before it passes through a hepatocytes-laden bioreactor. We aim to develop a hybrid bioreactor that integrates the separate modules in one compact design improving the efficacy of the cryogel based bioreactor as a bioartificial liver support. A plasma separation membrane and an activated carbon cloth are placed over a HepG2-loaded cryogel scaffold in a three-chambered bioreactor design. This bioreactor is consequently connected extracorporeally to a rat model of acute liver failure for 3 h and major biochemical parameters studied. Bilirubin and aspartate transaminase showed a percentage decrease of 20–60% in the integrated bioreactor as opposed to 5–15% in the conventional setup. Urea and ammonia levels which showed negligible change in the conventional setup increase (40%) and decrease (18%), respectively in the integrated system. Also, an overall increase of 5% in human albumin in rat plasma indicated bioreactor functionality in terms of synthetic functions. These results were corroborated by offline evaluation of patient plasma. Hence, integrating the plasmapheresis and adsorbent units with the bioreactor module in one compact design improves the efficacy of the bioartificial liver device.

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mentioning

confidence: 99%

Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support

Damania

Hassan

Shirakigawa

et al. 2017

Sci Rep

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Artificial Liver Bioreactor Design

Cited by 1 publication

References 137 publications

Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support

Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support

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