Artificial liposomes as a model for studying the lipid peroxidation effect of p-phenylene diamine

Abstract

The effect of p-phenylene diamine on the peroxidation of liposomized samples of lecithin and peanut oil was studied under optimal conditions. The p-phenylene diamine was found to affect the formation of thiobarbituric acid reactive products of lipid peroxidation and the efficacy of various free radical scavengers.

Studies on the interaction of p‐phenylene diamine with phospholipids

“…Single dermal application of p-phenylene diamine in guinea pigs caused pathomorphological lesions of skin over a period of 24 h, which were reduced on dermal application of superoxide dismutase [3]. The effect of p-phenylene diamine on the peroxidation of liposomized lecithin vesicles showed increased levels of formation of thiobarbituric acid-reactive products of lipid peroxidation [4]. Further, the increase in the glutathione-5-transferase activity of p-phenylene diamine exposed skin suggested the development of xenobiotic conjugation mechanism as a defence adaptation in dermal toxicity [ 5 ] .…”