“…In these circumstances, the use of artificial intelligence really seems to be a valuable tool in helping patients suffering from acute appendicitis, not only in diagnosing the condition but also in guiding treatment, whether surgical or not, and in preventing postoperative complications. 3 Appendicitis has been considered for decades a disease where surgery was mandatory to avoid severe morbidity or death; the so-called negative appendectomy being a necessary evil far better than missing a complicated appendicitis. This idea reaches recent times, when with the advent of minimally invasive surgery for the management of right iliac fossa pain, appendectomy during diagnostic laparoscopy has been advised even in case of no inflammation found.…”