Artificial intelligence in preventive and managed healthcare

Shenoy, Snehal; Sanap, Gaurav; Paul, Debleena; Desai, Nimeet; Tambe, Vishakha; Kalyane, Dnyaneshwar; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814425-1.00003-6

Cited by 5 publications

(2 citation statements)

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“…These imaging data provide invaluable insights into the size, shape, location, and surrounding tissue architecture of the defect. Based on these data, additive manufacturing technologies such as 3D printing can be leveraged, wherein NFMS can possibly be integrated as part of the “bio-ink” that forms patient-specific NFMS-integrated scaffolds. , As it would be designed to closely match the dimensions and contours of the patient’s bone defect, it would promote optimal fit and contact with the surrounding tissue for improved integration and functionality. , Bioactive factors can be incorporated into the NFMS matrix using spatially controlled deposition methods, allowing for the creation of gradient or multilayered scaffolds that mimic the native tissue microenvironment and promote enhanced tissue regeneration . Moreover, personalized NFMS-based therapies can harness patient-derived cells and bioactive factors to further augment bone healing outcomes.…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

“… 200 , 201 As it would be designed to closely match the dimensions and contours of the patient’s bone defect, it would promote optimal fit and contact with the surrounding tissue for improved integration and functionality. 202 , 203 Bioactive factors can be incorporated into the NFMS matrix using spatially controlled deposition methods, allowing for the creation of gradient or multilayered scaffolds that mimic the native tissue microenvironment and promote enhanced tissue regeneration. 204 Moreover, personalized NFMS-based therapies can harness patient-derived cells and bioactive factors to further augment bone healing outcomes.…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

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Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Desai,

Chavda,

Singh

et al. 2024

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Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art in cancer nanovaccine development, elucidating innovative strategies and technologies employed in their design. It explores both preclinical and clinical advancements, emphasizing key studies demonstrating their potential to elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, and the impact of nanoscale properties on vaccine performance. Detailed insights into the complex interplay between the tumor microenvironment and nanovaccine responses are provided, highlighting challenges and opportunities in optimizing therapeutic outcomes. Additionally, the study presents a thorough analysis of ongoing clinical trials, presenting a snapshot of the current clinical landscape. By curating the latest scientific findings and clinical developments, this study aims to serve as a comprehensive resource for researchers and clinicians engaged in advancing cancer immunotherapy. Integrating nanotechnology into vaccine design holds immense promise for revolutionizing cancer treatment paradigms, and this review provides a timely update on the evolving landscape of cancer nanovaccines.

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