Artificial heart in Russia: Past, present, and future

Gautier, S. V.; Шевченко, А. О.; Itkin, G. P.; Захаревич, В. М.; Попцов, В. Н.; Drobyshev, A. A.; Telyshev, D. V.

doi:10.1111/aor.13860

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…Subsequently to gel electrophoresis, the separated proteins were transferred to a PVDF membrane (#1704150, BioRad, Feldkirchen, Germany), blocked, washed and incubated [ 35 ]. Chemiluminescent signals were detected after incubation of the membrane with SuperSignal West Femto Substrate (34094, Thermo Fisher Scientific, Langerwehe, Germany), using the ChemiDoc Imaging System (BioRad, Karlsruhe, Germany).…”

Section: Methodsmentioning

confidence: 99%

Comparison of the Hemocompatibility of an Axial and a Centrifugal Left Ventricular Assist Device in an In Vitro Test Circuit

Borchers

Winnersbach

Kraemer

et al. 2022

JCM

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Background: Hemocompatibility of left ventricular assist devices is essential for preventing adverse events. In this study, we compared the hemocompatibility of an axial-flow (Sputnik) to a centrifugal-flow (HeartMate 3) pump. Methods: Both pumps were integrated into identical in vitro test circuits, each filled with 75 mL heparinized human blood of the same donor. During each experiment (n = 7), the pumps were operated with equal flow for six hours. Blood sampling and analysis were performed on a regular schedule. The analytes were indicators of hemolysis, coagulation activation, platelet count and activation, as well as extracellular vesicles. Results: Sputnik induced higher hemolysis compared to the HeartMate 3 after 360 min. Furthermore, platelet activation was higher for Sputnik after 120 min onward. In the HeartMate 3 circuit, the platelet count was reduced within the first hour. Furthermore, Sputnik triggered a more pronounced increase in extracellular vesicles, a potential trigger for adverse events in left ventricular assist device application. Activation of coagulation showed a time-dependent increase, with no differences between both groups. Conclusions: This experimental study confirms the hypothesis that axial-flow pumps may induce stronger hemolysis compared to centrifugal pumps, coming along with larger amounts of circulating extracellular vesicles and a stronger PLT activation.

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Section: Methodsmentioning

confidence: 99%

Comparison of the Hemocompatibility of an Axial and a Centrifugal Left Ventricular Assist Device in an In Vitro Test Circuit

Borchers

Winnersbach

Kraemer

et al. 2022

JCM

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“…In parallel with the development of TAHs in the USA, important and substantial contributions to the field were made behind the Iron Curtain. In the former Soviet Union, collaboration between professor Valery Ivanovich Shumakov and dr. Michael DeBakey resulted in the TAH called “Poisk‐10M.” From 1987 to 1991, 17 end‐stage heart failure patients (13 in the Soviet Union and 4 in Poland) received the “Poisk‐10M” TAH 11 . Furthermore, at Brno Research Center in former Czechoslovakia a comprehensive TAH program was established.…”

Section: The First Bridge To Transplantation In Europe Using a Tahmentioning

confidence: 99%

Bjarne K. H. Semb: The contriver of the first implantation of a total artificial heart in Europe

2022

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and he completed his training in general and thoracic surgery at Rikshospitalet in Oslo.Semb defended his doctoral thesis at the University of Oslo in 1971 with the title: Cardiac Transplantation: An Experimental Study in Dogs (Figure 1A). 1 Christiaan Barnard was a co-author on two of the articles in Semb's doctoral thesis (Figure 1B). Before Barnard performed the first human heart transplantation in South Africa, Barnard and Semb had formed part of the kidney transplant team in 1966 under the leadership of David M. Hume at the Medical College of Virginia in Richmond, VA. Together with Hume, Semb published his first academic article in 1968 on allogenic lymphocytes in an experimental kidney model. 2 Before completion of his training in Oslo as a cardiac surgeon he did extensive experimental research on regulators of gastric mucosal flow. After his return to Rikshospitalet, he did clinical studies on the early version of the Hall-Kaster disc valve prosthesis.In 1984, Viking Olov Björk retired from his dual position in Stockholm, and Semb was recruited for his knowledge of heart transplantations and was appointed head of the Department of Cardiothoracic Surgery at the Karolinska Hospital as well as professor of Thoracic Surgery at the Karolinska Institute.

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“…Our group has also deeply investigated the relationship between pump power consumption and blood flow rate [56]. This relationship was studied for two generations of CF RBPs: (1) The first generation of Sputnik LVAD that was successfully implemented into clinical practice [57,58], and (2) the second generation under development, which is aimed at miniaturization and reducing the risk of blood cell trauma [44]. The nonlinear relationship between blood flow rate and power consumption demonstrates that the minimum power consumption cannot be obtained at the point of zero flow in the pump [37].…”

Section: Applicability For Physiological Pump Controlmentioning

confidence: 99%

Correlation between Myocardial Function and Electric Current Pulsatility of the Sputnik Left Ventricular Assist Device: In-Vitro Study

et al. 2021

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This study assesses the electric current parameters and reports on the analysis of the associated degree of myocardial function during left ventricular assist device (LVAD) support. An assumption is made that there is a correlation between cardiac output and the pulsatility index of the pump electric current. The experimental study is carried out using the ViVitro Pulse Duplicator System with Sputnik LVAD connected. Cardiac output and cardiac power output are used as a measure of myocardial function. Different heart rates (59, 73, 86 bpm) and pump speeds (7600–8400 rpm in 200 rpm steps) are investigated. In our methodology, ventricular stroke volumes in the range of 30–80 mL for each heart rate at a certain pump speed were used to simulate different levels of contractility. The correlation of the two measures of myocardial function and proposed pulsatility index was confirmed using different correlation coefficients (values ≥ 0.91). Linear and quadratic models for cardiac output and cardiac power output versus pulsatility index were obtained using regression analysis of measured data. Coefficients of determination for CO and CPO models were in the ranges of 0.914–0.982 and 0.817–0.993, respectively. Study findings suggest that appropriate interpretation of parameters could potentially serve as a valuable clinical tool to assess myocardial therapy using LVAD infrastructure.

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Artificial heart in Russia: Past, present, and future

Cited by 9 publications

References 24 publications

Comparison of the Hemocompatibility of an Axial and a Centrifugal Left Ventricular Assist Device in an In Vitro Test Circuit

Comparison of the Hemocompatibility of an Axial and a Centrifugal Left Ventricular Assist Device in an In Vitro Test Circuit

Bjarne K. H. Semb: The contriver of the first implantation of a total artificial heart in Europe

Correlation between Myocardial Function and Electric Current Pulsatility of the Sputnik Left Ventricular Assist Device: In-Vitro Study

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