Artificial gravity with ergometric exercise can prevent enhancement of popliteal vein compliance due to 4-day head-down bed rest

Yao, Yu; Zhu, Yong; Yang, Cuixia; Zhou, Xiaodong; Sun, Xuegang

doi:10.1007/s00421-011-2083-0

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…After 3 wk of HDT, Platts et al (83) saw a 20% decrease in leg artery wall thickness, and Palombo et al (81) reported "inward remodeling" of the femoral artery, both of which imply vascular smooth muscle atrophy from chronic unloading. Leg venous compliance may not change in microgravity (117), and simulation methods produce variable results (12,31,111,125).…”

Section: Cardiovascular Functionmentioning

confidence: 99%

Analogs of microgravity: head-down tilt and water immersion

Watenpaugh

2016

Journal of Applied Physiology

102

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This article briefly reviews the fidelity of ground-based methods used to simulate human existence in weightlessness (spaceflight). These methods include horizontal bed rest (BR), head-down tilt bed rest (HDT), head-out water immersion (WI), and head-out dry immersion (DI; immersion with an impermeable elastic cloth barrier between subject and water). Among these, HDT has become by far the most commonly used method, especially for longer studies. DI is less common but well accepted for long-duration studies. Very few studies exist that attempt to validate a specific simulation mode against actual microgravity. Many fundamental physical, and thus physiological, differences exist between microgravity and our methods to simulate it, and between the different methods. Also, although weightlessness is the salient feature of spaceflight, several ancillary factors of space travel complicate Earth-based simulation. In spite of these discrepancies and complications, the analogs duplicate many responses to 0 G reasonably well. As we learn more about responses to microgravity and spaceflight, investigators will continue to fine-tune simulation methods to optimize accuracy and applicability.

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Section: Cardiovascular Functionmentioning

confidence: 99%

Analogs of microgravity: head-down tilt and water immersion

Watenpaugh

2016

Journal of Applied Physiology

102

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Moderate Exercise Based on Artificial Gravity Preserves Orthostatic Tolerance and Exercise Capacity During Short-Term Head-Down Bed Rest

Yang²,

Zhu³

et al. 2017

Physiol Res

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Numerous countermeasures have been proposed to minimize microgravity-induced physical deconditioning, but their benefits are limited. The present study aimed to investigate whether personalized aerobic exercise based on artificial gravity (AG) mitigates multisystem physical deconditioning. Fourteen men were assigned to the control group (n=6) and the countermeasure group (CM, n=8). Subjects in the CM group were exposed to AG (2 Gz at foot level) for 30 min twice daily, during which time cycling exercise of 80-95 % anaerobic threshold (AT) intensity was undertaken. Orthostatic tolerance (OT), exercise tests, and blood assays were determined before and after 4 days head-down bed rest (HDBR). Cardiac systolic function was measured every day. After HDBR, OT decreased to 50.9 % and 77.5 % of pre-HDBR values in control and CM groups, respectively. Exercise endurance, maximal oxygen consumption, and AT decreased to 96.5 %, 91.5 % and 91.8 % of pre-HDBR values, respectively, in the control group. Nevertheless, there were slight changes in the CM group. HDBR increased heart rate, sympathetic activity, and the pre-ejection period, but decreased plasma volume, parasympathetic activity and left-ventricular ejection time in the control group, whereas these effects were eliminated in the CM group. Aldosterone had no change in the control group but increased significantly in the CM group. Our study shows that 80-95 % AT aerobic exercise based on 2 Gz of AG preserves OT and exercise endurance, and affects body fluid regulation during short-term HDBR. The underlying mechanisms might involve maintained cardiac systolic function, preserved plasma volume, and improved sympathetic responses to orthostatic stress.

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Artificial gravity with ergometric exercise can prevent enhancement of popliteal vein compliance due to 4-day head-down bed rest

Cited by 2 publications

References 33 publications

Analogs of microgravity: head-down tilt and water immersion

Analogs of microgravity: head-down tilt and water immersion

Moderate Exercise Based on Artificial Gravity Preserves Orthostatic Tolerance and Exercise Capacity During Short-Term Head-Down Bed Rest

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