Artificial Fever Therapy of Syphilis

Studies in the Physiology of Artificial Fever. I. Changes in the Blood Volume and Water Balance

“…In one case treated with typhoid vaccine and in two cases treated by diathermy additional heating in the form of radiant energy (carbon filament lamp) was used. In 13 studies, 3 of which were made at Dayton, Ohio, fever was induced by hot moist circulating air in the "Kettering Hypertherm " (27). In the 10 studies made in Boston the relative humidity in the cabinet was maintained between 30 and 50 per cent during induction of fever.…”

Fever therapy for general paresis

“…Ultimately, they found that hot air alone, controlled by a thermostat, worked as effectively as it had with the short‐wave radio field. 29 …”

“…Ultimately, they found that hot air alone, controlled by a thermostat, worked as effectively as it had with the shortwave radio field. 29 A number of other techniques for raising body temperature were devised, some being remarkably simple. The ''inductotherm'' (Fig.…”

“…Treatment consisted of a total of 50-160 h of fever, usually given 5-8 h at a time, and with patient body temperature reaching up to 41°C. 29,33 ''Artificial fever'' was reported to produce results similar to malaria therapy. A literature review in 1938 found that, in 967 patients with general paresis treated by ''artificial fever,'' complete remission was reported in 27%, improvement in 36%, and death resulting from treatment in 2%.…”