Artificial Estrogens

Grundy, Jesse

doi:10.1021/cr50014a002

Cited by 65 publications

(22 citation statements)

References 172 publications

(246 reference statements)

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“…[17][18][19] DES, a potential estrogen, has been used medically as a substitute for endogenous estrogen and as a hormonal therapy for prostate or breast cancer, and also to prevent threatened abortions. 20,21) However, it may induce vaginal adenocarcinoma.…”

Section: Activation Of Trans-stilbene and Related Compounds By The Cymentioning

confidence: 99%

Metabolic Activation of Proestrogens in the Environment by Cytochrome P450 System

Kawa

Sugihara

Sanoh

et al. 2008

JOURNAL OF HEALTH SCIENCE

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Liver microsome-mediated activation of proestrogens in the environment is reviewed here. Proestrogens such as methoxychlor, trans-stilbene, diphenyl, diphenylmethane, 2,2-diphenylpropane, benzo[a]pyrene, benzophenone, 2-nitrofluorene (NF), chalcone, trans-4-phenyl-3-buten-2-one and styrene oligomers are negative in in vitro estrogen screening tests. However, those proestrogens exhibit estrogenic activity after metabolic activation by the microsomal cytochrome P450 system. In these cases, hydroxylated derivatives of the compounds are formed as major metabolites, and these metabolites exhibit significant estrogenic activities. Thus, the estrogenic activities of proestrogenic compounds are a consequence of metabolism of the parent compounds. Various candidates for proestrogens among medicines and insecticides are also discussed.

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Section: Activation Of Trans-stilbene and Related Compounds By The Cymentioning

confidence: 99%

Metabolic Activation of Proestrogens in the Environment by Cytochrome P450 System

Kawa

Sugihara

Sanoh

et al. 2008

JOURNAL OF HEALTH SCIENCE

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“…Stilbene itself does not occur in nature but hydroxylated and methylated stilbenes are found in medicinal plants.Stilbene derivatives such as diethylstilbestrol(DES), euvestin, 4,4' diaminostilbene and pinosylvin, have a variety of biological action, including hormonal, hypo cholesterolemic, sympathomimetic, antifungal, anti allergic, antibacterial, anti malarial and anticancer activities. [5][6][7][8] . DES is the mostfamous stilbene derivative, which was used medically for prostate and breast cancerand to preventthreatened abortions [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of some Novel Stilbene Derivatives Derived from Substituted (Phenyl Acetic Acid, Benzaldehyde, Amines) Triethyl Amine and Thionyl Chloride

Singh

2015

ILCPA

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ABSTRACT:Stilbene derivatives are widely distributed in the nature and they possess various bioactivities that includes antimicrobial, antifungal, antioxidant, hepato protective, anti-HIV, cytotoxic, antiinflammatory and antiplatelet. We have synthesized novel derivatives of stilbenes by reacting various substituted phenyl acetic acid with aldehydes in presence of acetic anhydride and triethyl amine. These derivatives were characterised by various spectral techniques and were evaluated for their antimicrobial activities.

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“…Stilbene derivatives such as diethylstilbestrol (DES) euvestin, 4,4'-diaminostilbene and pinosylvin, have a variety of biological action, including hormonal, hypocholesterolic, sympathomimetic, antifungal, antiallergic, antibacterial, antimalarial and anticancer activities [7][8][9][10]. Resveratrol (4,3,5-trihydroxy stilbene) which is present in grapes, peanuts, pine apple and also grape product such as wine , exert potent anti-oxidant and anti inflammatory activities [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Ester Derivatives of Stilbene Derived from Acid Derivative (of P-Chloro Phenyl Acetic Acid, Substitute Benzaldehyde, Triethyl Amine) with Methanol and Sulphuric Acid

Singh

2015

ILCPA

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Two stilbene derivatives have been synthesized in two step process. First step involved synthesis of acid derivative from p-chloro phenyl acetic acid, substituted benzaldehyde and triethyl amine, where as the second step involved synthesis of substituted stilbene derivatives (enoate or esters) through very simple route . These derivatives were characterized by various spectral techniques and were screened for their antimicrobial activities.

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Artificial Estrogens

Cited by 65 publications

References 172 publications

Metabolic Activation of Proestrogens in the Environment by Cytochrome P450 System

Metabolic Activation of Proestrogens in the Environment by Cytochrome P450 System

Synthesis and Characterization of some Novel Stilbene Derivatives Derived from Substituted (Phenyl Acetic Acid, Benzaldehyde, Amines) Triethyl Amine and Thionyl Chloride

Synthesis and Characterization of Ester Derivatives of Stilbene Derived from Acid Derivative (of P-Chloro Phenyl Acetic Acid, Substitute Benzaldehyde, Triethyl Amine) with Methanol and Sulphuric Acid

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