Artificial Control of Cell Signaling and Growth by Magnetic Nanoparticles

Lee, Jae-Hyun; Kim, Eun Sook; Cho, Mi Hyeon; Son, Mina; Yeon, Soo-In; Shin, Jeon Soo; Cheon, Jinwoo

doi:10.1002/ange.201001149

Cited by 24 publications

(30 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…92b, 104 Moreover, receptor-mediated artificial triggering of cell growth in preangiogenesis, which is a vital process both for the growth and development of blood vessels and for tumor metastasis stage 105 , has been successfully controlled by magnetic antibody-conjugated NPs binding the Tie2 receptor. 106 …”

Section: Activation Of Mechanotransduction Receptors and Mechano-sensmentioning

confidence: 99%

Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

Rauch¹,

Kölch²,

et al. 2013

View full text Add to dashboard Cite

Introduction 3391 2. Medical Applications of Nanomaterials 3391 2.1. Use of Nanomaterials in Diagnostic Applications 3392 3. Interaction of Nanomaterials with Living Cells 3392 3.1. Role of Physicochemical NP Properties in the Interaction between NPs and Biological Systems 3393 3.2. NP Uptake into the Cells 3393 3.2.1. Role of Size and Shape in NP Uptake 3393 3.2.2. Role of Surface Charge and Protein Corona on NP Uptake 3395 3.3. Activation of Signal Processing Pathways by NPs 3397 3.3.1. Interaction of NPs with Cell Membrane Receptors 3397 3.3.2. Role of Oxidative Stress and ROS in NP-Induced Signaling 3398 3.3.3. NPs Induce Cell Death Pathways 3400 3.3.4. Activation of Mechanotransduction Receptors by Magnetic NPs 3400 4. Magnetic NPs and Cell Signaling 3400 4.1. Controlled Activation of Cell Surface Receptors by Magnetic NPs 3400 4.1.1. Activation of Signal Transduction Receptors by Magnetic NPs 3400 4.1.2. Activation of Mechanotransduction Receptors and Mechanosensitive Signaling Pathways by Magnetic NPs 3400 4.2. Pathway Activation by Magnetic-NP-Induced Hyperthermia 3401 4.2.1. Molecular Targets of Hyperthermia: Heat Shock Proteins and p53 3401 5. Conclusions 3402 Author Information 3402 Corresponding Author 3402 Present Address 3402 Notes 3402 Biographies 3402 Acknowledgments 3403 References 3403

show abstract

Section: Activation Of Mechanotransduction Receptors and Mechano-sensmentioning

confidence: 99%

Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

Rauch¹,

Kölch²,

et al. 2013

View full text Add to dashboard Cite

show abstract

“…An additional advantage of using these two types of external stimuli is that they can be applied and removed instantaneously, and thus pave the way towards fabricating materials whose structures and properties can be modulated 'on demand'. For example, magnetic fields have been used to control the movement and assembly of magnetite [6][7][8] , cobalt 9,10 and other 11 superparamagnetic NPs, which gives rise to diverse functions and applications, including magnetically switchable catalysis 12,13 , water purification 14 and the remote control of intracellular signalling 15,16 . Despite these advances, this strategy requires magnetically responsive components.…”

mentioning

confidence: 99%

Light-controlled self-assembly of non-photoresponsive nanoparticles

et al. 2015

View full text Add to dashboard Cite

The ability to guide the assembly of nanosized objects reversibly with external stimuli, in particular light, is of fundamental importance, and it contributes to the development of applications as diverse as nanofabrication and controlled drug delivery. However, all the systems described to date are based on nanoparticles (NPs) that are inherently photoresponsive, which makes their preparation cumbersome and can markedly hamper their performance. Here we describe a conceptually new methodology to assemble NPs reversibly using light that does not require the particles to be functionalized with light-responsive ligands. Our strategy is based on the use of a photoswitchable medium that responds to light in such a way that it modulates the interparticle interactions. NP assembly proceeds quantitatively and without apparent fatigue, both in solution and in gels. Exposing the gels to light in a spatially controlled manner allowed us to draw images that spontaneously disappeared after a specific period of time.

show abstract

“…The manipulation and control of cells and sub-cellular structures through the magnetic nanoparticle-based actuation (nanomagnetic actuation) of cellular processes is a hot research topic (33)(34)(35). Recent studies have demonstrated that it is possible to manipulate and control cell function with an external magnetic field and specific magnetic labeling of the cell surface receptors (36,37).…”

Section: Discussionmentioning

confidence: 99%