Artifacts, anatomical and physiological variants, and unrelated diseases that might cause false-positive whole-body 131-I scans in patients with thyroid cancer

Shapiro, Brahm; Rufini, Vittoria; Jarwan, Ayman; Geatti, Onelio; Kearfott, Kimberlee J.; Fig, Lorraine M.; Kirkwood, Ian; Gross, Milton D.

doi:10.1053/nm.2000.5414

Cited by 138 publications

(95 citation statements)

References 122 publications

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“…It has been reported and discussed in literatures [2][3][4][5][6][7][8] that nonphysiological extra-thyroidal I-131 accumulation on I-131 WBS does not always imply thyroid cancer metastasis. We reported a rare case of special hair artifact with the form of a patch of crescent intense activity on left side of head.…”

Section: Discussionmentioning

confidence: 99%

Hair Artifact on the Left Side of Head Mimicking Metastasis of Thyroid Carcinoma in a Woman after I-131 Therapy

Cai

Jiang

et al. 2015

International Journal of Radiology

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Accurate interpretation of radioiodine whole body scan is extremely crucial to avoid unwarranted radioiodine ablative therapy in patients with differentiated thyroid carcinoma. We reported a rare case of special hair artifact in a 32-year-old woman on post-therapeutic scans which showed a crescent intense activity on the left lateral head, like neo-appeared metastasis. Additional projections after the hair was moved aside demonstrated that the activity was caused by hair contamination, likely from sialorrhea during sleep. The report enriches artifacts on radioiodine scans.

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Section: Discussionmentioning

confidence: 99%

Hair Artifact on the Left Side of Head Mimicking Metastasis of Thyroid Carcinoma in a Woman after I-131 Therapy

Cai

Jiang

et al. 2015

International Journal of Radiology

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“…uptake is passive diffusion of the tracer into the cyst (21). In some cases of false-positive I-131 uptake in simple cysts, the inflammation-induced exchange of water and chemical substances between the cyst and surrounding tissues is thought to be a possible mechanism (6,7).…”

Section: Discussionmentioning

confidence: 99%

False-positive Radioiodine Uptake in a Functional Ovarian Cyst in a Patient Treated with Total Thyroidectomy for Papillary Cancer

Jang

Kim

et al. 2013

Intern. Med.

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False positive radioiodine uptake following thyroidectomy for differentiated thyroid cancer has been reported in some cases. A 42-year-old woman was referred for ablative radioiodine treatment six weeks after undergoing total thyroidectomy for papillary thyroid carcinoma. Posttherapeutic I-131 scintigraphy showed an intense hot spot in the left pelvis. Pelvic computed tomography (CT) revealed a benign left ovarian mass such as a functional cyst. After menstruation, ultrasonographic imaging demonstrated a shrunken ovarian mass. Therefore, we diagnosed the patient with a functional cyst that was influenced by hormonal fluctuation. It is believed that this is the first case of false-positive radioiodine uptake in a functional ovarian cyst.

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“…In addition, extrathyroidal tissues, such as stomach, salivary glands, and breast, are known to express NIS, and these organs are capable of physiologic uptake of iodine [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…However, the mechanism by which ovarian neoplasms unrelated to thyroid tissue take up I-131 is still unclear. The suggested mechanisms of radioiodine uptake in the ovarian cystadenoma include increased vascularity and capillary permeability that might be secondary to inflammatory response associated with neoplasm [4,5]. In the ovarian endometrial cyst, the epithelium lining of the cyst may be permeable to passive diffusion [4][5][6].…”

Section: Discussionmentioning

confidence: 99%

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Ovarian Teratoma Mimicking Metastasis on I-131 Scan : A Case Report

Yoon

Hong

2012

Nucl Med Mol Imaging

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The whole body I-131 scan is routinely performed in the postoperative treatment of patients with welldifferentiated thyroid cancer. Accurate interpretation of whole body I-131 scan after thyroidectomy is critical to appropriate management of patients with thyroid cancer, to prevent unnecessary surgical removal or exposure to radioiodine. Unfortunately, false-positive uptakes in several other organs and their associated disease processes have been reported. We report a case of false-positive iodine uptake in the pelvic region with incidentally diagnosed mature cystic teratoma.

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Artifacts, anatomical and physiological variants, and unrelated diseases that might cause false-positive whole-body 131-I scans in patients with thyroid cancer

Cited by 138 publications

References 122 publications

Hair Artifact on the Left Side of Head Mimicking Metastasis of Thyroid Carcinoma in a Woman after I-131 Therapy

Hair Artifact on the Left Side of Head Mimicking Metastasis of Thyroid Carcinoma in a Woman after I-131 Therapy

False-positive Radioiodine Uptake in a Functional Ovarian Cyst in a Patient Treated with Total Thyroidectomy for Papillary Cancer

Ovarian Teratoma Mimicking Metastasis on I-131 Scan : A Case Report

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