Articulation of an alumina-zirconia composite ceramic against living cartilage – An in vitro wear test

Wimmer, Markus A.; Pacione, Carol; Yuh, Catherine; Chan, Yuet-Ming; Kunze, J.; Michel, Laurent; Chubinskaya, Susan

doi:10.1016/j.jmbbm.2019.103531

Cited by 11 publications

(8 citation statements)

References 41 publications

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“…Cell survival was measured using calcein acetoxymethyl and ethidium homodimer–1 (EthD-1; Molecular Probes). 51 Live cells emit green fluorescence after metabolizing calcein via a ubiquitous intracellular esterase, while EthD-1 enters cells when plasma membrane integrity is compromised after cell death, staining nuclear DNA red. Cell viability was recorded as the number of live cells divided by the number of total cells.…”

Section: Methodsmentioning

confidence: 99%

Effect of Mechanical Mincing on Minimally Manipulated Articular Cartilage for Surgical Transplantation

et al. 2022

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Background: Point-of-care treatment options for medium to large symptomatic articular cartilage defects are limited. Minced cartilage implantation is an encouraging single-stage option, providing fresh viable autologous tissue with minimal morbidity and cost. Purpose: To determine the histological properties of mechanically minced versus minimally manipulated articular cartilage. Study Design: Controlled laboratory study. Methods: Remnant articular cartilage was collected from fresh femoral condylar allografts. Cartilage samples were divided into 4 groups: cartilage explants with or without fibrin glue and mechanically minced cartilage with or without fibrin glue. Samples were cultured for 42 days. Chondrocyte viability was assessed using live/dead assay. Cellular migration and outgrowth were monitored using bright-field microscopy. Extracellular matrix deposition was assessed via histological staining. Proteoglycan content and synthesis were assessed using dimethylmethylene blue assay and radiolabeled 35S-sulfate, respectively. Type II collagen (COL2A1) gene expression was analyzed via polymerase chain reaction. Results: The mean viability of minced cartilage particles (34% ± 14%) was not significantly reduced compared with baseline (46% ± 13%) on day 0 ( P = .90). After culture, no significant difference in the percentage of live cells was appreciated between mechanically minced (58% ± 23%) and explant (73% ± 14%) cartilage in the presence of fibrin glue ( P = .52). The addition of fibrin glue did not significantly affect the viability of cartilage samples. The qualitative assessment revealed comparable cellular migration and outgrowth between groups. Proteoglycan synthesis was not significantly different between groups. Histological analysis findings were positive for COL2A1 in all groups, and matrix formation was appreciated in all groups. COL2A1 expression in minced cartilage (1.72 ± 1.88) was significantly higher than in explant cartilage (0.15 ± 0.07) in the presence of fibrin glue ( P = .01). Conclusion: Mechanically minced articular cartilage remained viable after 42 days of culture in vitro and was comparable with cartilage explants with regard to cellular migration, outgrowth, and extracellular matrix synthesis. Clinical Relevance: Mechanically minced articular cartilage is an encouraging intervention for the treatment of symptomatic cartilage defects. Further translational work is warranted to determine the viability of minced cartilage implantation as a single-stage therapeutic intervention in vivo.

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Section: Methodsmentioning

confidence: 99%

Effect of Mechanical Mincing on Minimally Manipulated Articular Cartilage for Surgical Transplantation

et al. 2022

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“…Most of these studies did not consider the living nature and live chondrocyte cells of articular cartilage addressed in Ref. [623]. Furthermore, a single, often simplified, loading and motion were applied, while the importance of considering more realistic combined inputs was recognized [624].…”

Section: Natural Synovial Joints and Artificial Joint Replacementsmentioning

confidence: 99%

A review of advances in tribology in 2020–2021

Meng

et al. 2022

Friction

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Around 1,000 peer-reviewed papers were selected from 3,450 articles published during 2020–2021, and reviewed as the representative advances in tribology research worldwide. The survey highlights the development in lubrication, wear and surface engineering, biotribology, high temperature tribology, and computational tribology, providing a show window of the achievements of recent fundamental and application researches in the field of tribology.

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“…Natural joints are "soft-soft" contact pairs due to the natural cartilage, a highly hydrated biological tissue covering the joint surface, that can effectively reduce shock impact, absorb shock, reduce the impact of joint movement, and lower impact abrasion [3]. The common artificial hemi hip replacement materials are CoCrMo alloys and zirconia ceramics, forming "hard-soft" contact pairs with cartilage, resulting in severe cartilage wear, osteolysis, aseptic loosening, and prosthesis failure [4][5][6], leading to a gap with natural joints. Qian and Shirong [7] used natural articular cartilage/ceramics to carry out a tribological test on reciprocating motion tests to explore the wear of hemi hip replacements.…”

Section: Introductionmentioning

confidence: 99%

“…Vanlommel et al [8] compared the damage of porcine patellar cartilage by OxZr and CoCr, and the results showed that both implants could cause cartilage surface degradation. Wimmer et al [6] evaluated the effect of an alumina-zirconia composite (AZC) as a joint interface against living cartilage graft, and compared with clinicalrelated CoCrMo; AZC induced less cell and tissue damage than CoCrMo. Stojanovic et al [9] studied the friction corrosion effect of the interface of CoCrMo alloys and cartilage during the sliding process, indicating that the release of metal ions and particles will form compounds with potential cytotoxicity to cartilage tissue.…”

Section: Introductionmentioning

confidence: 99%

Bio-tribological behavior of articular cartilage based on biological morphology

Zhang

Chen

et al. 2021

J Mater Sci: Mater Med

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Artificial hemiarthroplasty is one of the effective methods for the treatment of hip joint diseases, but the wear failure of the interface between the hemi hip joint material and articular cartilage restricts the life of the prosthesis. Therefore, it is important to explore the damage mechanism between the interfaces to prolong the life of the prosthesis and improve the life quality of the prosthesis replacement. In this paper, the creep and bio-tribological properties of cartilage against PEEK, CoCrMo alloy, and ceramic were studied, and the tribological differences between “hard–soft” and “soft–soft” contact were analyzed based on biomorphology. The results showed that with the increase of time in vitro, the thickness of the cartilage membrane decreased, the surface damage was aggravated, and the anti-creep ability of cartilage was weakened. Second, the creep resistance of the soft–soft contact pair was better than that of the hard–soft contact pair. Also, the greater the load and the longer the wear time, the more serious the cartilage damage. Among the three friction pairs, the cartilage in PEEK/articular cartilage was the least damaged, followed by CoCrMo alloy/articular cartilage, and the most damage was found in ceramic/articular, indicating that the soft–soft friction pair inflicted the least damage to the cartilage.

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Articulation of an alumina-zirconia composite ceramic against living cartilage – An in vitro wear test

Cited by 11 publications

References 41 publications

Effect of Mechanical Mincing on Minimally Manipulated Articular Cartilage for Surgical Transplantation

Effect of Mechanical Mincing on Minimally Manipulated Articular Cartilage for Surgical Transplantation

A review of advances in tribology in 2020–2021

Bio-tribological behavior of articular cartilage based on biological morphology

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