Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

O'Shea, Donagh G; Curtin, Caroline M.; O’Brien, Fergal J.

doi:10.1039/d1bm01540k

Cited by 23 publications

(20 citation statements)

References 293 publications

(408 reference statements)

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“…A large number of such biofabrication studies assess capacity for repair in small animal models, especially rabbits, and these have been reviewed by others. [115,266] Only a few of these advanced strategies have been applied to large animal models, and none yet to humans. For example, He et al generated cartilage ex situ by culturing autologous BM-MSCs on a PGA/PLA scaffold for various time periods (2, 4, or 8 weeks) before implanting in a pig model of an osteochondral defect.…”

Section: Results From Pre-clinical and Clinical Trialsmentioning

confidence: 99%

Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair

O’Connell

Duchi

Onofrillo

et al. 2022

Adv Healthcare Materials

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Human articular cartilage has a poor ability to self-repair, meaning small injuries often lead to osteoarthritis, a painful and debilitating condition which is a major contributor to the global burden of disease. Existing clinical strategies generally do not regenerate hyaline type cartilage, motivating research toward tissue engineering solutions. Prospective cartilage tissue engineering therapies can be placed into two broad categories: i) Ex situ strategies, where cartilage tissue constructs are engineered in the lab prior to implantation and ii) in situ strategies, where cells and/or a bioscaffold are delivered to the defect site to stimulate chondral repair directly. While commonalities exist between these two approaches, the core point of distinction-whether chondrogenesis primarily occurs "within" or "without" (outside) the body-can dictate many aspects of the treatment. This difference influences decisions around cell selection, the biomaterials formulation and the surgical implantation procedure, the processes of tissue integration and maturation, as well as, the prospects for regulatory clearance and clinical translation. Here, ex situ and in situ cartilage engineering strategies are compared: Highlighting their respective challenges, opportunities, and prospects on their translational pathways toward long term human cartilage repair.

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Section: Results From Pre-clinical and Clinical Trialsmentioning

confidence: 99%

Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair

O’Connell

Duchi

Onofrillo

et al. 2022

Adv Healthcare Materials

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“…[44][45][46] Triphasic osteochondral scaffolds developed using various designs are considered as promising and effective attempts to improve osteochondral regeneration. 47,48 In most of the cases, the interlayer was a mixed zone of the upper cartilage scaffold components and the bottom bone scaffold components. 49 And in some other cases, a dense layer was placed between the upper and bottom zones, exerting the barrier function of the native CCL.…”

Section: Discussionmentioning

confidence: 99%

Strategy of a cell-derived extracellular matrix for the construction of an osteochondral interlayer

Gao

et al. 2022

Biomater. Sci.

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“…3D printing of cartilaginous structures with zonal configurations fosters the development of personalized engineered scaffolds. [71][72][73] For example, the combination of calcium phosphate cement (CPC) with mesoporous silica (MS) has been 3Dprinted according to the shape of the patient's injured site. The hydrogel based on hydroxybutyl chitosan (HBC) crosslinked with oxidized CS (OCS) is 3D-printed on top and the in vivo results after subcutaneous implantation of the scaffolds into the dorsal region of nude mice show that MS/CPC promotes angiogenesis and subchondral bone development.…”

Section: Mechanical Properties Of Biopolymersmentioning

confidence: 99%

Recent Advances in “Functional Engineering of Articular Cartilage Zones by Polymeric Biomaterials Mediated with Physical, Mechanical, and Biological/Chemical Cues”

Dehghan-Baniani

Mehrjou

Chu

et al. 2023

Adv Healthcare Materials

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Articular cartilage (AC) plays an unquestionable role in joint movements but unfortunately the healing capacity is restricted due to its avascular and acellular nature. While cartilage tissue engineering has been lifesaving, it is very challenging to remodel the complex cartilage composition and architecture with gradient physio-mechanical properties vital to proper tissue functions. To address these issues, a better understanding of the intrinsic AC properties and how cells respond to stimuli from the external microenvironment must be better understood. This is essential in order to take one step closer to producing functional cartilaginous constructs for clinical use. Recently, biopolymers have aroused much attention due to their versatility, processability, and flexibility because the properties can be tailored to match the requirements of AC. This review highlights polymeric scaffolds developed in the past decade for reconstruction of zonal AC layers including the superficial zone, middle zone, and deep zone by means of exogenous stimuli such as physical, mechanical, and biological/chemical signals. The mimicked properties are reviewed in terms of the biochemical composition and organization, cell fate (morphology, orientation, and differentiation), as well as mechanical properties and finally, the challenges and potential ways to tackle them are discussed.

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Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

Abstract: In the human body, articular cartilage facilitates the frictionless movement of synovial joints. However, due to its avascular and aneural nature, it has a limited ability to self-repair when damaged...

Cited by 23 publications

References 293 publications

Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair

Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair

Strategy of a cell-derived extracellular matrix for the construction of an osteochondral interlayer

Recent Advances in “Functional Engineering of Articular Cartilage Zones by Polymeric Biomaterials Mediated with Physical, Mechanical, and Biological/Chemical Cues”

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