Articular cartilage transplantation

Pritzker, Kenneth P.H.; Gross, Allan E.; Länger, F; Luk, S. C.; Houpt, Joseph B.

doi:10.1016/s0046-8177(77)80093-2

Cited by 52 publications

(28 citation statements)

References 16 publications

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“…Another key requirement of prolonged FOCA survival is the mechanical stability at the host-graft interface [30,39,50]. Only with a stable interface can the host bone grow appositionally on graft bone trabeculae and eventually replace the graft bone by creeping substitution, including the bone of the subchondral plate.…”

Section: Discussionmentioning

confidence: 99%

Fresh Osteochondral Allografts for Posttraumatic Knee Defects: Long-term Followup

Gross¹,

Kim²,

Heras³

et al. 2008

Clin Orthop Relat Res

222

177

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Fresh osteochondral allograft transplantation has been an effective treatment option with promising long-term clinical outcomes for focal posttraumatic defects in the knee for young, active individuals. We examined histologic features of 35 fresh osteochondral allograft specimens retrieved at the time of subsequent graft revision, osteotomy, or TKA. Graft survival time ranged from 1 to 25 years based on their time to reoperation. Histologic features of early graft failures were lack of chondrocyte viability and loss of matrix cationic staining. Histologic features of late graft failures were fracture through the graft, active and incomplete remodeling of the graft bone by the host bone, and resorption of the graft tissue by synovial inflammatory activity at graft edges. Histologic features associated with long-term allograft survival included viable chondrocytes, functional preservation of matrix, and complete replacement of the graft bone with the host bone. Given chondrocyte viability, long-term allograft survival depends on graft stability by rigid fixation of host bone to graft bone. With the stable osseous graft base, the hyaline cartilage portion of the allograft can survive and function for 25 years or more.

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Section: Discussionmentioning

confidence: 99%

Fresh Osteochondral Allografts for Posttraumatic Knee Defects: Long-term Followup

Gross¹,

Kim²,

Heras³

et al. 2008

Clin Orthop Relat Res

222

177

View full text Add to dashboard Cite

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“…[7] Viability of chondrocytes is the most critical factor for good clinical outcomes of osteochondral allograft transplantation, as they maintain the extracellular matrix, and, thereby, the function of cartilage tissue over time. In cryopreserved cartilage, cell survival rate has been shown to be quite poor, about 20-30%, [8] and even though fresh, refrigerated cartilage retains higher viability, prolonged storage of fresh human osteochondral allograft tissue for more than 14 days has been demonstrated to lead to significant decreases in chondrocyte viability, viable cell density, and metabolic activity.…”

Section: Osteochondral Allograft Transplantationmentioning

confidence: 99%

Clinical experiences with cartilage repair techniques: outcomes, indications, contraindications and rehabilitation

Berta

Duska

Tóth

et al. 2015

Eklem Hastalik Cerrahisi

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“…The initial application of osteoarticular grafts was with large segmental joint transplantation with large portions of bone. Notably, avascular bone requires extensive time to be replaced or incorporated through creeping substitution and thus bony collapse or insufficiency fractures were not uncommon [61]. Because chondral and osteochondral nonneoplastic lesions of the knee typically are associated with minimal involvement of the subchondral bone, Bugbee and Convery [7] recommended osteochondral allografts have the least amount of bone possible to minimize these adverse consequences.…”

Section: Fresh Osteochondral Allograftsmentioning

confidence: 99%

Clinical Cartilage Restoration: Evolution and Overview

Farr

Cole

Dhawan

et al. 2011

Clinical Orthopaedics &Amp; Related Research

210

166

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Background Clinical cartilage restoration is evolving, with established and emerging technologies. Randomized, prospective studies with adequate power comparing the myriad of surgical techniques used to treat chondral injuries are still lacking and it remains a challenge for the surgeon treating patients to make evidence-based decisions. Questions/purposes We reviewed the history of the major cartilage repair/restorative procedures, indications for currently available repair/restorative procedures, and postoperative management. Methods We performed searches using MEDLINE and cartilage-specific key words to identify all Englishlanguage literature. Articles were selected based on their contributions to our current understanding of the basic science and clinical treatment of articular cartilage lesions or historical importance. We then selected 77 articles, two of which are articles of historical importance. Results Current cartilage restorative techniques include débridement, microfracture, osteochondral fragment repair, osteochondral allograft, osteochondral autograft, and autologous chondrocyte transplantation. Pending techniques include two-staged cell-based therapies integrated into a variety of scaffolds, single-stage cell-based therapy, and augmentation of marrow stimulation, each with suggested indications including lesion size, location, and activity demands of the patient. The literature demonstrates variable improvements in pain and function contingent upon multiple variables including indications and application. Conclusions For the patient with symptomatic chondral injury, numerous techniques are available to the surgeon to relieve pain and improve function. Until rigorous clinical trials (prospective, adequately powered, randomized control) are available, treatment decisions should be guided by expert extrapolation of the available literature based in historically sound principles.

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Articular cartilage transplantation

Cited by 52 publications

References 16 publications

Fresh Osteochondral Allografts for Posttraumatic Knee Defects: Long-term Followup

Fresh Osteochondral Allografts for Posttraumatic Knee Defects: Long-term Followup

Clinical experiences with cartilage repair techniques: outcomes, indications, contraindications and rehabilitation

Clinical Cartilage Restoration: Evolution and Overview

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