Articular cartilage. Strong adsorption and cohesion of phospholipids with the quaternary ammonium cations providing satisfactory lubrication of natural joints

Mreła, Aleksandra; Pawlak, Zenon

doi:10.1016/j.biosystems.2018.12.005

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…The phospholipid molecules in the SAPL exhibit a unique amphiphilic behavior possessing positive quaternary ammonium ions and negative phosphate ions. The quaternary ammonium (QA) ions has strong electrostatic bond strength and thus able to bind to surfaces with excess negative charges [4][5][6][7][8][9][10][11][12][13]. Since the proteoglycan molecules in the articular surface have excess carboxyl and sulphate ions, the surface of cartilage is attractive to the QA ions, thereby leaving the excess phosphate ions accessible for the positive mobile ions (Na + , Ca 2+ , H + ) present in the synovial fluid [4,13].…”

Section: Resultsmentioning

confidence: 99%

Atomic force microscope observation of the surfaces of natural articular cartilage

Pawlak¹

2022

JSCRI

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Hydrophilic and negatively charged natural cartilage surface is covered by phospholipids bilayers. These phospholipids have been demonstrated to exert highly desirable characteristics on the surface articular cartilage such as efficient lubrication, load processing, and semipermeability for nutrient transport. We examined a bovine cartilage (BC) surface using atomic force microscope. The study was performed using cartilage samples with healthy surfaces and completely depleted surface phospholipids. The artificially degraded cartilage surfaces (lipid depleted) were resurfaced with different species and combinations of synthetic bilayer of phospholipids found in human joints. Our results demonstrated that it is possible to recreate a potentially viable layer of phospholipids on the surface of degenerated cartilage. However, further studies will be required to advance the resurfacing idea developed in this paper for the potential treatment of osteoarthritis and other related orthopedic joint conditions.

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Section: Resultsmentioning

confidence: 99%

Atomic force microscope observation of the surfaces of natural articular cartilage

Pawlak¹

2022

JSCRI

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“…Phospholipids, associated with HA through electrostatic or hydrophobic interactions, expose their hydrophilic phosphorylcholine groups. [57,58] These biomacromolecules endow articular cartilage with remarkable compressibility and elasticity, thus facilitating the effective absorption of impact forces and the dispersion of stress.…”

Section: Mechanisms Of Cartilage Lubricationmentioning

confidence: 99%

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Yang,

Zhang

2024

Adv Funct Materials

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Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting disease progression. This review illuminates novel approaches in OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural joint lubrication, show promise in restoring joint biomechanics and alleviating pain. The review delves into an array of biomimetic lubricants, including polymer brush, nanocomposite hydrogel, and nanoparticles, underscoring their roles in anti‐inflammation, targeting, cartilage repair, and drug delivery. Furthermore, the potential of mesenchymal stem cells to differentiate into chondrocytes, coupled with the delivery of these cells and their exosomes via nanomaterials, has promoted cell therapy avenues for OA. The review also highlights the function of non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, and antisense oligonucleotides in impeding OA progression, with nanomaterials facilitating their delivery, thus facilitating advanced therapeutic possibilities including immune evasion and bone cell proliferation. Overall, this review encapsulates the evolution of nanomaterials in OA treatment from material to cell, and ultimately to gene therapy, forecasting a future where nanomaterials evolve toward integrated, personalized diagnostics and therapeutics for OA.

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Functional nano drug delivery system with dual lubrication and immune escape for treating osteoarthritis

Yang,

Yan,

Chen

et al. 2023

Journal of Colloid and Interface Science

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Articular cartilage. Strong adsorption and cohesion of phospholipids with the quaternary ammonium cations providing satisfactory lubrication of natural joints

Cited by 6 publications

References 17 publications

Atomic force microscope observation of the surfaces of natural articular cartilage

Atomic force microscope observation of the surfaces of natural articular cartilage

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Functional nano drug delivery system with dual lubrication and immune escape for treating osteoarthritis

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