Articular Cartilage Repair With Bioscaffolds

Hydrogel implant is as effective as osteochondral autologous transplantation for treating focal cartilage knee injury in 24 months

“…Aging is an important factor that should be considered for determining surgical treatment approaches. Several studies have shown that elderly patients have more implant complications [4, 9, 11, 13, 14, 16, 20, 23, 24, 27, 29]. In this paper, the Hydrogel group was younger than were the samples in these previous studies (our sample's mean age was 33.6 years).…”

Clinical Trials with Mesenchymal Stem Cell Therapies for Osteoarthritis: Challenges in the Regeneration of Articular Cartilage

“…Total joint replacement is the last suitable intervention for end-stage degenerative OA, but early surgical strategies with which to repair osteochondral lesions are also available, such as microfracture (MF), autologous chondrocyte implantation (ACI), autologous matrix-induced chondrogenesis (AMIC), and matrix-assisted autologous chondrocyte implantation (MACI) [ 13 ]. The abovementioned cell-based cartilage defect repair strategies, as well as cell-free approaches, such as osteotomy, graft transplantation, and the implantation of scaffold biomaterials, are often inevitable therapies because of the limited self-regenerating ability of the articular cartilage tissue [ 14 , 15 ]; however, it is difficult to obtain durable, biomimetic, and weight-bearing hyaline-like cartilage repair for these surgical interventions. Therefore, there is an unattained need for new developments in the treatment of OA to prevent the progression of cartilage degeneration [ 13 , 14 , 15 ].…”

“…The abovementioned cell-based cartilage defect repair strategies, as well as cell-free approaches, such as osteotomy, graft transplantation, and the implantation of scaffold biomaterials, are often inevitable therapies because of the limited self-regenerating ability of the articular cartilage tissue [ 14 , 15 ]; however, it is difficult to obtain durable, biomimetic, and weight-bearing hyaline-like cartilage repair for these surgical interventions. Therefore, there is an unattained need for new developments in the treatment of OA to prevent the progression of cartilage degeneration [ 13 , 14 , 15 ]. The objective of this article is to review clinical trials that used MSC therapies in the treatment of OA, aiming to evaluate their outcome measures, effectiveness, and quality in the regeneration of articular cartilage.…”