Articular Cartilage: In Vivo Diffusion-Tensor Imaging

Raya, José G.; Horng, Annie; Dietrich, Olaf; Krasnokutsky, Svetlana; Beltrán, Luis; Storey, Pippa; Reiser, Maximilian; Recht, Michael P.; Sodickson, Daniel K.; Gläser, Christian

doi:10.1148/radiol.11110821

Cited by 100 publications

(97 citation statements)

References 41 publications

(45 reference statements)

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“…Although diffusion imaging may supplement other quantitative techniques for evaluating cartilage, clinical studies that use the technique are rare. However, in 1 study, diffusion tensor imaging showed excellent reproducibility and may be able to differentiate healthy from OA subjects 19 . Clinical studies examining the potential role of gagCEST in the assessment of OA-related cartilage degeneration are lacking.…”

Section: Rheumatologymentioning

confidence: 87%

Compositional Magnetic Resonance Imaging Measures of Cartilage — Endpoints for Clinical Trials of Disease-modifying Osteoarthritis Drugs?

2016

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Section: Rheumatologymentioning

confidence: 87%

Compositional Magnetic Resonance Imaging Measures of Cartilage — Endpoints for Clinical Trials of Disease-modifying Osteoarthritis Drugs?

2016

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“…DTI parameters MD and FA provide an exquisite and useful tool for non-invasive and intravoxel investigation of human tissue microstructures [27][28][29]. However, the application of DTI to the cancellous bone is not completely straightforward, as diffusion MRI in this area is hampered by the need for fat suppression, high b values and by the scarce amount of water with a subsequent low signal [45].…”

Section: Discussionmentioning

confidence: 99%

“…From DTI measurements, it is possible to derive the mean diffusivity (MD) of water in tissues and various measures of its diffusion anisotropy, such as the fractional anisotropy (FA). DTI has been extensively used to study the structure of ordered biological tissue [27][28][29]. In this work, we hypothesized that MD may be sensitive to the mean pore size increase in cancellous bone and that FA may be sensitive to variations of trabecular network anisotropy which occur with the onset of the osteoporotic disease.…”

Section: Introductionmentioning

confidence: 99%

Diffusion tensor imaging and magnetic resonance spectroscopy assessment of cancellous bone quality in femoral neck of healthy, osteopenic and osteoporotic subjects at 3T: Preliminary experience

Manenti

Capuani

Fanucci

et al. 2013

Bone

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H-MRS)Bone marrow fat fraction (FF) Femur Osteoporosis Fractional anisotropy (FA) We assessed the potential of diffusion tensor imaging (DTI) in combination with proton magnetic resonance spectroscopy ( 1 H-MRS), in cancellous bone quality evaluation of the femoral neck in postmenopausal women. Introduction: DTI allows for non-invasive microarchitectural characterization of heterogeneous tissue. In this work we hypothesized that DTI parameters mean diffusivity (MD) and fractional anisotropy (FA) of bone marrow water, can provide information about microstructural changes that occur with the development of osteoporosis disease. Because osteoporosis is associated with increased bone marrow fat content, which in principal can alter DTI parameters, the goal of this study was to examine the potential of MD and FA, in combination with bone marrow fat fraction (FF), to discriminate between healthy, osteopenic and osteoporotic subjects, classified according to DXA criteria. Materials and methods: Forty postmenopausal women (mean age, 68.7 years; range 52-81 years), underwent a Dual-energy X-ray absorptiometry (DXA) examination in femoral neck, to be classified as healthy (n = 12), osteopenic (n = 14) and osteoporotic (n = 14) subjects. ) of femoral neck were obtained in each subject at 3T. The study protocol was approved by local Ethics Committee. MD, FA, FF and MD/FF, FA/FF were obtained and compared among the three bone-density groups. One-way ANOVA with multiple comparisons Bonferroni test and Pearson correlation analysis were applied. Receiver operating characteristic (ROC) curve analysis was also performed. Results: Reproducibility of DTI measures was satisfactory. CV was approximately 2%-3% for MD and 4%-5% for FA measurements. Moreover, no significant difference was found in both MD and FA measurements between two separate sessions (median 34 days apart) comprised of six healthy volunteers. FF was able to discriminate between healthy and osteoporotic subjects only. Conversely MD and FA were able to discriminate healthy from osteopenic and healthy from osteoporotic subjects, but they were not able to discriminate between osteopenic and osteoporotic patients. A significant correlation between MD and FF was observed in healthy group only. A moderate correlation was found between MD and T-score when all groups together are considered. No significant correlation was found between MD and T-score within groups. A significant positive correlation between FA and FF was found in both osteopenic and osteoporotic groups. Vice-versa no correlation between FA and FF was observed in healthy group. A high significant positive correlation was found between FA and T-score in all groups together, in healthy and in osteoporotic groups. MD/FF and FA/FF are characterized by a higher sensitivity and specificity compared to MD and FA in the discrimination between healthy, and osteoporotic subjects. MD/FF vs FA/FF graph extracted from femoral neck, identify all healthy individuals according to DXA results. Conclusion: DTI-1 H-MRS proto...

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“…DTI parameters of ADC of water in the bone marrow can be quantified, which provides a useful tool for the noninvasive investigation of human tissues (36,37). ADC values reflect the association between the direction of the diffusion of water molecules and the organizational structure (38).…”

Section: A B C a B Cmentioning

confidence: 99%

Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head

Min

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to explore the potential diagnostic role of diffusion tensor magnetic resonance imaging (DTI) in the early stage of modified corticosteroid-induced osteonecrosis of the femoral head (ONFH). A total of 20 beagles were randomly classified (1:1) into either an experimental group (LM), which were intramuscularly injected with lipopolysaccharide (LPS) and methylprednisolone (MPS) on three consecutive days, or control (CON) group, which were injected with saline. Magnetic resonance imaging (MRI) and DTI were performed at pre-induction and 8 and 12 weeks post-induction. Apparent diffusion coefficient (ADC) values in the range of interest in the femoral head were quantified using DTI. Proximal femora were examined for ONFH at 8 and 12 weeks. The results demonstrated that ONFH developed in four beagles at 8 weeks and in six beagles at 12 weeks, whereas no ONFH was detected in the CON group. No abnormalities were detected by MRI and DTI, and no mortality occurred. In beagles with ONFH in the LM group, the ADC values were 4.7±0.2x10 -4 and 4.8±0.3x10 -4 mm 2 /sec at 8 and 12 weeks, respectively, which were significantly increased compared with the CON group (2.5±0.3x10 -4 and 2.4±0.3x10 -4 mm 2 , respectively) and the LM group without ONFH (2.6±0.4x10 -4 and 2.4±0.3x10 -4 mm 2 , respectively) (P<0.05). The results of the present study indicated that intramuscular injection of LPS and MPS may lead to early-stage ONFH in beagles. As such, the detection of locally elevated ADC values in the femoral head may aid in the early diagnosis of ONFH.

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Articular Cartilage: In Vivo Diffusion-Tensor Imaging

Abstract: In vivo DT imaging of patellar cartilage is feasible, has good test-retest reproducibility, and may be accurate in discriminating healthy subjects from subjects with OA. ADC and FA are two promising biomarkers for early OA.

Cited by 100 publications

References 41 publications

Compositional Magnetic Resonance Imaging Measures of Cartilage — Endpoints for Clinical Trials of Disease-modifying Osteoarthritis Drugs?

Compositional Magnetic Resonance Imaging Measures of Cartilage — Endpoints for Clinical Trials of Disease-modifying Osteoarthritis Drugs?

Diffusion tensor imaging and magnetic resonance spectroscopy assessment of cancellous bone quality in femoral neck of healthy, osteopenic and osteoporotic subjects at 3T: Preliminary experience

Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head

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