Article: Eicosapentaenoic Acid Blocks Cyclosporine A-Induced Pancreatic Dysfunction but not Immunosuppression
Abstract:Cyclosporine A (CsA) is a widely used immunosuppressant in transplantation medicine. However, it has oxidative stress-induced side effects, including nephrotoxicity, hypertension, dyslipidemia, and glucose intolerance; particularly, post-transplant diabetes mellitus, accompanied by alterations of pancreatic islet cells, has been reported as a major adverse event. Recent research indicates that omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA), have antioxidant and anti-inflammatory activ… Show more
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