Article Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice

Hu, Feng; Yan, Yu; Wang, Chu wang; Liu, Yu; Wang, Jing jing; Zhou, Fang; Zeng, Qing; Zhou, Xiao Yan; Chen, Jia; Wang, Ai‐Jun; Zhou, Jiayi

doi:10.1007/s11655-018-3060-9

Cited by 29 publications

(14 citation statements)

References 37 publications

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“…Indeed, gel-gluglycerosomes provided the more rapid and effective closure of skin lesions in the scratch assay, probably because of the ability of glucidex and/or its combination with gelatin, to promote cell proliferation to a better extent than the other components of the vesicles. This result is in agreement with previous studies reporting the wound healing promotion of different polysaccharides [ 76 , 77 ]. The most promising efficacy of gel-gluglycerosomes can also be due to the delayed and prolonged uptake provided by all glycerosomes in comparison with liposomes.…”

Section: Discussionsupporting

confidence: 94%

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

et al. 2020

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An extract of Hypericum scruglii, an endangered endemic plant of Sardinia (Italy), was prepared and characterized. It was loaded in special phospholipid vesicles, glycerosomes, which were modified by adding maltodextrin (glucidex) and a polymer (gelatin or hyaluronan). The corresponding liposomes were also prepared and used as reference. The vesicles disclosed suitable physicochemical features for skin delivery. Indeed, their mean diameter ranged from 120 to 160 nm, they were homogeneously dispersed (polydispersity index ≤ 0.30), and their zeta potential was highly negative (~−45 mV). The vesicle dispersions maintained unchanged characteristics during 60 days of storage, were highly biocompatible, and were able to protect keratinocytes against damages due to oxidative stress induced by treating them with hydrogen peroxide. Vesicles were also capable of promoting cell proliferation and migration in vitro by means of a scratch wound assay. The results confirmed the fruitful delivery of the extract of H. scruglii in glycerosomes modified with glucidex and gelatin and their promising ability for skin protection and treatment.

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Section: Discussionsupporting

confidence: 94%

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

et al. 2020

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“…This is a first report of such rapid and complete wound healing herbal compounds in sea cucumbers, where typically model organisms such as mice are used. Researches in the use of Chinese herbal medicines on wound healing have developed from simple morphology and tissue structure to cell biology, molecular biology and other fields (Farahpour & Habibi, 2012; Hou et al., 2015; Hu et al., 2019). Thus, the cellular and molecular analyses of herbal treatments in sea cucumbers are greatly needed.…”

Section: Discussionmentioning

confidence: 99%

Wound healing at the body wall of the sea cucumber Apostichopus japonicus by Chinese herbal treatment

et al. 2020

Aquac. Res.

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“…A total of three fetal rats were obtained from each pregnant rat, for a total of 54 fetal rats from both GA16.5 and GA18.5 groups, and the survival rate was calculated. Tissue samples from the surgical site on the upper-left lip and asymmetrical sections from the upper-right lip were collected from the fetal rats for histological examination, including hematoxylin and eosin (H&E) staining, Masson's Trichrome staining and type-I collagen immunohistochemical staining as previously described ( 14 – 16 ).…”

Section: Methodsmentioning

confidence: 99%

Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip

Liu

et al. 2021

Mol Med Rep

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in early pregnancy, fetal skin wounds can heal quickly and undergo a transition period from scarless healing to scar formation. The aim of the present study was to identify potential biomarkers associated with scarless repair of cleft lips, in order to determine the intrinsic factors leading to scar formation in embryonic tissue. a stable model of cleft lip was established using microsurgery by constructing a wedge-shaped cleft lip-like defect in fetal rats at gestational age (Ga) 16.5 and Ga18.5. The Ga16.5 and Ga18.5 groups were used to model scarless healing and scar formation, respectively. The fetuses were returned to the uterus following surgery, then removed 72 h after the procedure. Macroscopic observation of the cleft defect and histological examination were carried out. reverse transcription-quantitative (rT-q) Pcr and parallel reaction monitoring (PrM) were used to detect mrna and protein expression levels, respectively. The upper-left lip completely healed 72 h after surgery in the Ga16.5 group of fetal rats. However, this was not the case in the Ga18.5 group. Histological examination indicated new follicles visible under the epidermis of the scarless group (Ga16.5). Scarring was visible on the upper-left cleft lip wound of the fetal rats in the Ga18.5 group. The expression of some growth and pro-inflammatory factors, including TnF-α, were also different between two groups. Label-free quantification was used to identified differentially expressed proteins and five differentially expressed proteins (Smad4, Fabp5, S100a4, S100a8 and S100a9) were identified. The relative expression of these molecules at the mrna and protein levels were measured using rT-qPcr and PrM. These molecules may represent potential biomarkers for the scarless repair of fetal rat cleft lip wounds.

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Article Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice

Cited by 29 publications

References 37 publications

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

Wound healing at the body wall of the sea cucumber Apostichopus japonicus by Chinese herbal treatment

Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip

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