Article Commentary: Cost-Effective Screening for Breast Cancer Worldwide: Current State and Future Directions

Sarvazyan, Armen; Egorov, Vladimir; Son, Jae Sung; Kaufman, Cary S.

doi:10.4137/bcbcr.s774

Cited by 37 publications

(30 citation statements)

References 58 publications

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“…However, mammography raises controversy due to low compliance, poor sensitivity [4], accumulated radiation exposure [5], discomfort due to breast compression [6] and over-diagnosis [7]. Furthermore, breast cancer screening programs are often not available in developing countries due to relatively high costs involved [8] and rural populations with limited access to specialized radiology clinics [9], requiring a low cost and less invasive modality to better meet screening demands.…”

Section: Introductionmentioning

confidence: 99%

Separate modal analysis for tumor detection with a digital image elasto tomography (DIET) breast cancer screening system

et al. 2013

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Digital Image Elasto Tomography (DIET) is a non-invasive breast cancer screening modality that induces mechanical vibrations into a breast and images its surface motion with digital cameras. A new approach in software based diagnosis of this surface motion is presented, focussing on the second natural frequency of the breast. Separate modal analysis is used to estimate the modal parameters using imaging data from silicone phantoms. The second natural frequency proves to be a reliable metric with the potential to clearly distinguish cancerous and healthy tissue as well as providing an approximate location for the tumor. Furthermore, thorough statistical analysis is performed to verify the results.

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Section: Introductionmentioning

confidence: 99%

Separate modal analysis for tumor detection with a digital image elasto tomography (DIET) breast cancer screening system

et al. 2013

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“…This method provides a real-time 2D pressure pattern and elasticity map, and is termed as tactile imaging (TI), or ‘stress imaging’, or ‘mechanical imaging (MI)’ [26–28]. …”

Section: Introductionmentioning

confidence: 99%

Harmonic Motion Imaging (HMI) for Tumor Imaging and Treatment Monitoring

Konofagou¹,

Maleke²,

Vappou³

2012

CMIR

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Palpation is an established screening procedure for the detection of several superficial cancers including breast, thyroid, prostate, and liver tumors through both self and clinical examinations. This is because solid masses typically have distinct stiffnesses compared to the surrounding normal tissue. In this paper, the application of Harmonic Motion Imaging (HMI) for tumor detection based on its stiffness as well as its relevance in thermal treatment is reviewed. HMI uses a focused ultrasound (FUS) beam to generate an oscillatory acoustic radiation force for an internal, non-contact palpation to internally estimate relative tissue hardness. HMI studies have dealt with the measurement of the tissue dynamic motion in response to an oscillatory acoustic force at the same frequency, and have been shown feasible in simulations, phantoms, ex vivo human and bovine tissues as well as animals in vivo. Using an FUS beam, HMI can also be used in an ideal integration setting with thermal ablation using high-intensity focused ultrasound (HIFU), which also leads to an alteration in the tumor stiffness. In this paper, a short review of HMI is provided that encompasses the findings in all the aforementioned areas. The findings presented herein demonstrate that the HMI displacement can accurately depict the underlying tissue stiffness, and the HMI image of the relative stiffness could accurately detect and characterize the tumor or thermal lesion based on its distinct properties. HMI may thus constitute a non-ionizing, cost-efficient and reliable complementary method for noninvasive tumor detection, localization, diagnosis and treatment monitoring.

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“…Traditional methods for early detection of breast cancer, including physical examination, mammography, ultrasound, and magnetic resonance imaging (MRI), are limited by low sensitivity and specificity for pre-malignant lesions [55][56][57][58][59][60][61]. In addition, these imaging methods do not give molecular information.…”

Section: Part B -Rice Universitymentioning

confidence: 99%

Harnessing the Power of Light to See and Treat Breast Cancer

Ramanujam¹

2013

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) U.S. Army Medical Research And Material Command SPONSOR/MONITOR'S ACRONYM(S)Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for public release; distribution unlimited. SUPPLEMENTARY NOTESOur objective is to exploit the wealth of physiological, metabolic, morphological and molecular sources of optical contrast to develop novel strategies that focus on two breast cancer applications: tumor margin assessment and prediction of response to neo-adjuvant therapy. The proposed aims of this grant are expected to result in three major contributions. The first has the most immediate impact. An optically based strategy that can quickly and non-destructively detect positive tumor margins will decrease the need for re-excision surgery and thereby decrease the local recurrence rate and rate of distant metastases in women electing BCS. Gaining insight into the physiological, metabolic, morphological and molecular sources of heterogeneity within and among tumors and how they are modulated by therapy, drug resistance and metastatic potential will directly benefit prognostication, prediction of outcome and planning of cancer therapies. With these tools, clinicians and clinical researchers can get a better understanding of this disease and how it might react to a drug. Basic science researchers could use it as an informed approach to study tumor biology and assay the effect of novel therapeutic agents in vivo.

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Article Commentary: Cost-Effective Screening for Breast Cancer Worldwide: Current State and Future Directions

Cited by 37 publications

References 58 publications

Separate modal analysis for tumor detection with a digital image elasto tomography (DIET) breast cancer screening system

Separate modal analysis for tumor detection with a digital image elasto tomography (DIET) breast cancer screening system

Harmonic Motion Imaging (HMI) for Tumor Imaging and Treatment Monitoring

Harnessing the Power of Light to See and Treat Breast Cancer

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