Artichoke leaf extract reduces mild dyspepsia in an open study

Marakis, Georgios; Walker, Ann F.; Middleton, Richard W.; Booth, J; Wright, John; Pike, Derek J.

doi:10.1078/094471102321621287

Cited by 36 publications

(21 citation statements)

References 12 publications

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“…[14][15][16] To date, placebo-controlled studies on the effects of ALE in the treatment of patients with functional dyspepsia are lacking. However, observational data for the artichoke leaf extract tested (ALE LI 220) from more than 1300 patients 17,18 have shown clear improvement of symptoms during treatment. While this beneficial effect might be due to a placebo effect or spontaneous fluctuation of symptom intensity, placebo-controlled trials are clearly needed to substantiate the efficacy of ALE.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six‐week placebo‐controlled, double‐blind, multicentre trial

Holtmann

Adam

Haag

et al. 2003

Aliment Pharmacol Ther

126

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SUMMARYBackground: This study aimed to assess the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD). Methods: In a double-blind, randomized controlled trial (RCT), 247 patients with functional dyspepsia were recruited and treated with either a commercial ALE preparation (2 · 320 mg plant extract t.d.s.) or a placebo. The primary efficacy variable was the sum score of the patient's weekly rating of the overall change in dyspeptic symptoms (four-point scale). Secondary variables were the scores of each dyspeptic symptom and the quality of life (QOL) as assessed by the Nepean Dyspepsia Index (NDI).

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Section: Introductionmentioning

confidence: 99%

Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six‐week placebo‐controlled, double‐blind, multicentre trial

Holtmann

Adam

Haag

et al. 2003

Aliment Pharmacol Ther

126

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“…A meta-analysis found Iberogast to be more effective at relieving symptoms than placebo [96] . Artichoke leaf extract may also improve some symptoms of dyspepsia [97,98] .…”

Section: Dyspepsiamentioning

confidence: 99%

Gastrointestinal Motility Disorders: An Update

Lacy

Weiser

2006

Dig Dis

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Gastrointestinal motility disorders encompass a wide array of signs and symptoms that can occur anywhere throughout the luminal gastrointestinal tract. Motility disorders are often chronic in nature and dramatically affect patients’ quality of life. These prevalent disorders cause a tremendous impact both to the individual patient and to society as a whole. Significant progress has been made over the last 5 years in understanding the etiology and pathophysiology of gastrointestinal motility disorders. This clinical update will focus on seven of the most common gastrointestinal motility disorders (achalasia, non-achalasia esophageal motility disorders, dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction, irritable bowel syndrome, and chronic constipation) with an emphasis on current treatment options and new therapeutic modalities.

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“…Luteolin, a flavone which inhibit the de novo cholesterol synthesis as well sesquiterpene lactones has coleretic and cholagogue effects (Saenz Rodriguez et al, 2002). The leaf extract of artichoke reduces mild dispepsia (Marakis et al, 2002) and have antioxidant potential, as demonstrated on leukocytes (Perez-Garcia et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Comparative Fingerprint and Extraction Yield of Medicinal Herb Phenolics with Hepatoprotective Potential, as Determined by UV-Vis and FT-MIR Spectroscopy

Zavoi

Fetea

Ranga

et al. 2011

Not Bot Hort Agrobot Cluj

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The present study was aimed to compare the polyphenolic composition of six medicinal herbs, from wild flora of Romania. The plants investigated, Cynara scolimus (artichoke), Taraxacum officinalis (dandelion), Chelidonium majus (celandine), Hypericum perforatum (St. John's wort), Silybum marianum (Mary thistle) and Lycopodium clavatum (Wolf 's claw) are known, to have hepatoprotective action. Using in parallel glycerol-water, ethanol-water and methanol, the solvent-dependence of the extract fingerprint and composition in bioactive molecules was studied by UV-Vis and Infrared (FT-MIR) spectrometry. The extraction yields, calculated as an extraction factor (EF) were superior in acidic methanol comparative to glycerin and ethanol, favorising the increase in phenolic acids against flavonoid derivatives . Based on the differences of polarity between the three solvents used, higher EF values were obtained for dandelion, artichoke, celandine and St. John wort, more rich in phenolic acids than flavonoids. Mary thistle and Wolf 's claw had lower concentrations of phenolics, but higher content of lignans and terpenoids. Based on the FT-MIR peaks from 8 regions, for each plant extract, has been determined the fingerprint region between 900 and 1500 cm -1 and identified the specific functional groups. A good, significant correlation was found between the concentration of total phenolics calculated by UV-Vis spectrometry and FTIR methods, after calibration with gallic acid. The value of the MIR signal at 1743 cm -1 may be considered a good indicator of phenolics concentration in such extracts. Combined UV-Vis and FTIR spectroscopy are recommended as rapid and reliable tools to investigate the fingerprint and to predict the composition of medicinal plants or to evaluate the quality and authenticity of different standardized formulas.

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Artichoke leaf extract reduces mild dyspepsia in an open study

Cited by 36 publications

References 12 publications

Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six‐week placebo‐controlled, double‐blind, multicentre trial

Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six‐week placebo‐controlled, double‐blind, multicentre trial

Gastrointestinal Motility Disorders: An Update

Comparative Fingerprint and Extraction Yield of Medicinal Herb Phenolics with Hepatoprotective Potential, as Determined by UV-Vis and FT-MIR Spectroscopy

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