Artichoke and Green Coffee Seeds to Overcome Hepatopathy induced by Carbon Tetrachloride in Rats

Abstract

This study aimed to investigate the effect of diets enriched with artichoke and green coffee seeds powders on hepatopathy rats.Twenty five adult male albino rats (Sprague Dawley strain), weighting (160±10g) used in this study and assigned to two main groups. The first is a negative control group (5 rats) was received a basal diet throughout the experiment .The second group (20 rats) was injected s/c by (0.2ml/kg) carbon tetrachloride for two weeks, twice a week. The percent of plants seeds which were used 7% artichoke seeds, 7%green coffee seeds and 7%mix of them from the basal diet.Serum liver function (AST, ALT and ALP), (SOD, GPx and CAT), (total protein, albumin and globulin), ( total bilirubin, direct bilirubin and indirect bilirubin), total cholesterol and triglycerides, lipoproteins (VLDL-c, HDL-c, LDL-c) were determined, kidney function was also assessed (urea, creatinine, uric acid).The results revealed that, the control (+ve) group showed a significant increase in (ALT, AST, ALP)c ompared with the control (-ve) 7% green ‫التطبيقـــية‬ ‫العـلوم‬ ‫و‬ ‫النوعيـــة‬ ‫للتربيــــة‬ ‫العلمــــية‬ ‫المجــلة‬ esThe Scientific Journal of Specific Education and Applied Scienc 28 coffee seeds powder was the best results, the results of (total protein, albumin and globulin) showed a significant increase in negative control compared with the control (+ve) (7% mix of artichoke and green coffee seeds powder) was the best results, but the results of lipid profile, kidney function and (total bilirubin, direct bilirubin, indirect bilirubin) revealed that, the control (+ve) group showed a significant increase in its compared with the control (-ve) (7% mix of artichoke and green coffee seeds powder) was the best results of lipid profile and kidney function but (7% artichoke seeds powder) was the best results of (total bilirubin, direct bilirubin, indirect bilirubin), on the other hand the control (+ve) group showed a significant decrease in (SOD, GPx, CAT) compared with the control (-ve) (7% mix of artichoke seeds powder) was the best results.The obtained results concluded that feeding with artichoke and green coffee seeds powder improved, liver function, kidney function and lipid profile. RecommendationsAccording to the results of this study, which showed the importance of both artichoke and green coffee seeds powder in improving liver and kidney functions and blood lipids because they contain antioxidants and phenolic compounds so we have recommended the use of them as a drinks to improve hepatopathy, the current study recommended to more interested in the effect of artichoke and green coffee seeds powder on other diseases such as heart disease, obesity, diabetes and cancer.