Artichoke and bergamot extracts: a new opportunity for the management of dyslipidemia and related risk factors

Arnaboldi, Lorenzo; Corsini, Alberto; Bellosta, Stefano

doi:10.23736/s0026-4806.21.07950-7

Cited by 6 publications

(8 citation statements)

References 105 publications

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“…Various animal and human models indicate that artichoke extracts and products, including its juices, also exert cardioprotective potential [ 102 , 103 ]. For example, Roghani-Dehkordi and Kamkhah [ 85 ] report that artichoke leaf juice reduces blood pressure in subjects with mild hypertension and Wang et al [ 84 ] found artichoke bud extract to have beneficial effects in a rat model of hypertension.…”

Section: Biological Activity Of Different Parts Of C Scolymusmentioning

confidence: 99%

“…Artichoke may exert its cardioprotective properties via various mechanisms, including controlling obesity, oxidative stress, inflammation and lipid profile [ 102 , 103 ].…”

Section: Biological Activity Of Different Parts Of C Scolymusmentioning

confidence: 99%

“…Arnaboldi et al [ 103 ] report that supplementation with artichoke and bergamot extracts, either alone or in combination, has therapeutic potential in the treatment of mild to moderate dyslipidemia in patients with metabolic syndrome, hepatic steatosis or intolerance to statins or other drugs. In addition, Frigerio et al [ 58 ] found artichoke leaf extract to have beneficial effects on cholesterol homeostasis in vitro.…”

Section: Biological Activity Of Different Parts Of C Scolymusmentioning

confidence: 99%

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An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements

Olas

2024

Nutrients

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Cynara scolymus, also known as the globe artichoke or artichoke, is grown as a food, mainly in the Mediterranean, Canary Islands, and Egypt, as well as in Asia and South America. It has also been associated with various health benefits and is used in plant-based dietary supplements and herbal infusions. Its edible parts, consisting of the head or capitula, flower, and leaves, have shown various biological activities, including anti-cancer, hepatoprotective and antimicrobial potential. The leaves are mainly used in infusions and extracts for their health-promoting properties, although all their edible parts may also be consumed as fresh, frozen, or canned foods. However, its primary health-promoting activity is associated with its antioxidant potential, which has been linked to its chemical composition, particularly its phenolic compounds (representing 96 mg of gallic acid equivalent per 100 g of raw plant material) and dietary fiber. The main phenolic compounds in the heads and leaves are caffeic acid derivatives, while the flavonoids luteolin and apigenin (both present as glucosides and rutinosides) have also been identified. In addition, heat-treated artichokes (i.e., boiled, steamed or fried), their extracts, and waste from artichoke processing also have antioxidant activity. The present paper reviews the current literature concerning the biological properties of different parts of C. scolymus, its by-products and dietary supplements, as well as their chemical content and toxicity. The literature was obtained by a search of PubMed/Medline, Google Scholar, Web of Knowledge, ScienceDirect, and Scopus, with extra papers being identified by manually reviewing the references.

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Section: Biological Activity Of Different Parts Of C Scolymusmentioning

confidence: 99%

“…Artichoke may exert its cardioprotective properties via various mechanisms, including controlling obesity, oxidative stress, inflammation and lipid profile [ 102 , 103 ].…”

Section: Biological Activity Of Different Parts Of C Scolymusmentioning

confidence: 99%

Section: Biological Activity Of Different Parts Of C Scolymusmentioning

confidence: 99%

See 1 more Smart Citation

An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements

Olas

2024

Nutrients

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“…It is related to beneficial effects in atherosclerosis, biliary duct, digestive tract, and the treatment of scurvy and anemia (83). A recent review summarized beneficial effects of artichoke extracts on blood lipid concentrations after consumption of artichoke leaf extracts compared with placebo or reference pharmacological treatment (84). The active components of artichoke have been found to inhibit cholesterol synthesis and show relevant anti-inflammatory and antioxidant properties (85).…”

Section: Moving Beyond Ryr Extract: Alternative Nutraceutical Product...mentioning

confidence: 99%

“…Bergamot (C. bergamia) belongs to the Citrus fruits and differs from others Citrus fruits for its high-content of flavonoids and statin-like compounds (94). Bergamot-derived molecules have been shown to ameliorate plasma lipid profile and visceral fat in clinical trials (84,95). Specifically, among bergamot constituents, naringin, neoeriocitrin, and rutin were found to inhibit the oxidation of LDL particles (96).…”

Section: Moving Beyond Ryr Extract: Alternative Nutraceutical Product...mentioning

confidence: 99%

Nutraceutical alternatives to red yeast rice extract/monacolin K for moderate hypercholesterolaemia: Current evidence and knowledge gaps: Nutraceuticals and hypercholesterolaemia

Comi¹,

Giglione²,

Tolaj³

et al. 2023

European Atherosclerosis Journal

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The nutraceutical approach to moderate hypercholesterolaemia is an interesting option in the context of appropriate conditions associated with low cardiovascular risk, and red yeast rice (RYR) extract is one of the most utilized products in this field. Monacolin k, its main active component, reduces serum LDL-C levels via inhibition of β-Hydroxy β-methylglutaryl-CoA reductase, similarly to statins. In 2011, EFSA approved the claim regarding monacolin k from RYR extract and maintenance of normal cholesterol levels. However, in 2018, EFSA issued a warning about potential adverse effects of this nutraceutical and, in 2022, the European Commission published a Regulation with several limitations of its use. Therefore, current research and development efforts are aiming at assessing efficacy and safety of other known and novel nutraceutical products which may benefit patients with moderate hypercholesterolaemia. These active agents range from phytosterols, probiotics and berberine to bergamot, cabbage and artichoke extracts and soy protein. Moreover, plant extracts from traditional medicine, for example from African countries, are also a subject of study in this direction. The full clinical exploitation of many of them, however, still requires robust clinical evidence, which should be the objective of future research.

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L'anatomia del torace per lo specialista e per il medico generico

DEZZANI

2024

Gazz Med Ital - Arch Sci Med

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Artichoke and bergamot extracts: a new opportunity for the management of dyslipidemia and related risk factors

Cited by 6 publications

References 105 publications

An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements

An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements

Nutraceutical alternatives to red yeast rice extract/monacolin K for moderate hypercholesterolaemia: Current evidence and knowledge gaps: Nutraceuticals and hypercholesterolaemia

L'anatomia del torace per lo specialista e per il medico generico

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