Arthroscopy of the normal cadaveric ovine femorotibial joint: a systematic approach to the cranial and caudal compartments

Modesto, Rolf B; Mansmann, K. A.; Schaer, Thomas P.

doi:10.3415/vcot-14-03-0039

Cited by 4 publications

(2 citation statements)

References 38 publications

(37 reference statements)

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“…Careful valgus stress and elevation of the meniscus with a hooked probe was used to assist in visualization of the cartilage surfaces and menisci. 5,15 A standardized reporting form used to record the ICRS (International Cartilage Repair Society) cartilage defect grade for the medial condyle and tibial plateau joint surfaces. Video and still image recordings were made as part of the medical record.…”

Section: Methodsmentioning

confidence: 99%

“…Cake et al 4 described 3 arthrotomy methods by which the load sharing capacity of the meniscus was reduced and came to the conclusion that all methods created fissures and focal erosions in the medial compartment while sparing the lateral compartment. Diagnostic arthroscopy in the sheep knee has been assessed in normal 5,6 and postmeniscectomy sheep knees. 6 In life, assessments to characterize OA progression include ultrasonography, radiographs, computed tomography (CT), and magnetic resonance imaging (MRI) scans.…”

Section: Introductionmentioning

confidence: 99%

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Modeling and Staging of Osteoarthritis Progression Using Serial CT Imaging and Arthroscopy

et al. 2018

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Objective The objective of this study was to describe in life methods by which osteoarthritis can be staged in order to time therapeutic interventions that are relevant to osteoarthritis (OA) clinical trials Methods Twenty-two sheep underwent arthroscopic meniscal destabilization to induce OA. Serial computed tomography (CT) imaging and arthroscopy were used to monitor osteoarthritis progression at 3-month intervals over 9 months. Eleven sheep received 1 intra-articular injection of hyaluronate 3 months after OA induction and another group of 11 received saline. A linear mixed model was used to define the trajectory of shape change in the medial joint compartment. Ordinal logistic regression was used to investigate the association between morphological changes and sclerosis. Results Three months after meniscal destabilization there were early bipolar chondral lesions in the medial compartment of the knee, as well as osteophytes and bone remodeling. Superficial fissures and cartilage cracks progressed to discrete areas of cartilage thinning and fibrillation on the medial tibial plateau by 6 months that became cartilage erosions by nine months. A linear mixed effect model demonstrated significant change in medial compartment length and width with over time ( P < 0.05) for both groups. A significant association between severity of sclerosis and medial compartment morphology was also observed. Conclusions The induction of osteoarthritic lesions with meniscal release model can be followed using noninvasive and minimally invasive procedures allowing for real-time decisions about redosing therapies, or other changes such as extending trial timelines without sacrificing animals to conduct assessments.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modeling and Staging of Osteoarthritis Progression Using Serial CT Imaging and Arthroscopy

et al. 2018

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Irregular porous titanium enhances implant stability and bone ingrowth in an intra‐articular ovine model

Changoor

Suderman

Alshaygy

et al. 2022

Journal Orthopaedic Research

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Two commercially available porous coatings, Gription and Porocoat, were compared for the first time in a challenging intra‐articular, weight‐bearing, ovine model. Gription has evolved from Porocoat and has higher porosity, coefficient of friction, and microtextured topography, which are expected to enhance bone ingrowth. Cylindrical implants were press‐fit into the weight‐bearing regions of ovine femoral condyles and bone ingrowth and fixation strength evaluated 4, 8, and 16 weeks postoperatively. Biomechanical push‐out tests were performed on lateral femoral condyles (LFCs) to evaluate the strength of the bone‐implant interface. Bone ingrowth was assessed in medial femoral condyles (MFCs) as well as implants retrieved from LFCs following biomechanical testing using backscattered electron microscopy and histology. By 16 weeks, Gription‐coated implants exhibited higher force (2455 ± 1362 vs. 1002 ± 1466 N; p = 0.046) and stress (12.60 ± 6.99 vs. 5.14 ± 7.53 MPa; p = 0.046) at failure, and trended towards higher stiffness (11,510 ± 7645 vs. 5010 ± 8374 N/mm; p = 0.061) and modulus of elasticity (591 ± 392 vs. 256 ± 431 MPa; p = 0.061). A strong, positive correlation was detected between bone ingrowth in LFC implants and failure force (r = 0.93, p < 10−13). By 16 weeks, bone ingrowth in Gription‐coated implants in MFCs was 10.50 ± 6.31% compared to 5.88 ± 2.77% in Porocoat (p = 0.095). Observations of the bone‐implant interface, made following push‐out testing, showed more bony material consistently adhered to Gription compared to Porocoat at all three time points. Gription provided superior fixation strength and bone ingrowth by 16 weeks.

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Systematic arthroscopic investigation of the bovine stifle joint

Hagag

Tawfiek

Brehm

2015

The Veterinary Journal

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Arthroscopy of the normal cadaveric ovine femorotibial joint: a systematic approach to the cranial and caudal compartments

Abstract: The arthroscopic approach developed in this research is ideal to evaluate the ovine stifle joint.

Cited by 4 publications

References 38 publications

Modeling and Staging of Osteoarthritis Progression Using Serial CT Imaging and Arthroscopy

Modeling and Staging of Osteoarthritis Progression Using Serial CT Imaging and Arthroscopy

Irregular porous titanium enhances implant stability and bone ingrowth in an intra‐articular ovine model

Systematic arthroscopic investigation of the bovine stifle joint

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