Arthroscopic synovectomy of the knee in rheumatoid arthritis defined by the 2010 ACR/EULAR criteria

Triolo, Pierfranco; Rossi, Roberto; Rosso, Federica; Blonna, Davide; Castoldi, Filippo; Bonasia, Davide Edoardo

doi:10.1016/j.knee.2016.05.010

Cited by 9 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The arthroscopy was applied in RA patients with severe cartilage or bone destruction by synovial hyperplasia that results in joint dysfunction or disabilities. One of the two surgical approaches, total joint replacement, or synovectomy was applied with the patients’ consents ( 18 ). RA patients were classified according to the 1987 American College of Rheumatology (ACR) revised classification criteria ( 19 ) and exhibited moderate to severe disease activity (disease activity score of 28 joint counts >3.2).…”

Section: Methodsmentioning

confidence: 99%

Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling

et al. 2017

View full text Add to dashboard Cite

Fibroblast-like synoviocytes (FLSs) acquire aggressive phenotypes characterized with enhanced migration abilities and inherent invasive qualities in rheumatoid arthritis (RA). Smoothened (Smo) is a key component of sonic hedgehog (Shh) signaling and contributes to tumor cell invasion and metastasis. The objective of this study is to investigate the role of Smo in the modulation of cell migration and explore the underlying molecular mechanism(s). FLSs were isolated from RA synovium. Shh levels were regulated by a Smo agonist (purmorphamine), Smo antagonist (KAAD-cyclopamine), or small interfering RNA targeting the Smo gene (Smo-siRNA) in RA-FLSs. Expression of Smo was detected by real-time PCR and western blot analysis. Cell migration was examined by Transwell assay and activation of Rho GTPases was measured by pull-down assays. Incubation with purmorphamine resulted in a significant increase of cell migration and activation of Rho GTPase signaling compared to controls (P < 0.05). However, treatment with KAAD-cyclopamine or transfection with Smo-siRNA suppressed migration of RA-FLSs and showed an inhibitory effect of Rho GTPase signaling. Together, these results suggest that Smo plays an important role in RA-FLSs migration through activation of Rho GTPase signaling and may contribute to progression of RA, thus, targeting Shh signal may have a therapeutic potential in patients with RA.

show abstract

Section: Methodsmentioning

confidence: 99%

Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling

et al. 2017

View full text Add to dashboard Cite

show abstract

“…These results are similar to the results of our study, which observed a recurrence-free survival rate of 58.8% (five out of 15 patients) in RA at ten years. In a separate study focusing on arthroscopic synovectomy, Tirolo et al [25] analyzed the survival rates following this specific procedure. Their analysis indicated that 18 out of 66 knees, constituting 27.3% of the cases, needed subsequent revision procedures.…”

Section: Recurrence-free Survival Ratementioning

confidence: 99%

Recurrence-Free Survival after Synovectomy and Subsequent Radiosynoviorthesis in Patients with Synovitis of the Knee—A Retrospective Data Analysis

Schindler,

Puchner,

Reinhard

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Persistent knee synovitis leads to joint discomfort, incapacitating inflammation, and functional limitations. The conventional approach has involved surgical procedures to eliminate the actively inflamed synovial membrane. This study aims to investigate the recurrence-free survival and functional outcome after synovectomy and subsequent radiosynoviorthesis (RSO) in patients with knee synovitis. Methods: Thirty-seven knees diagnosed with pigmented villonodular synovitis (PVNS), rheumatoid arthritis (RA), and peripheral spondyloarthritis underwent synovectomy and subsequent RSO between May 2005 and October 2016. The mean age was 34.9 ± 15.1 years, and the mean follow-up period was 84 ± 36.4 months. Clinical outcomes were assessed using the Oxford Knee Score and the presence of swelling and pain at the last follow-up. Recurrence-free survival denotes the duration from synovectomy to surgical re-synovectomy. Results: In general, twelve knees underwent re-synovectomy after a mean follow-up of 34.8 ± 24.9 months. The recurrence-free survival was 83.8% at two years, 71.3% at five years, and 61.7% at ten years. The subgroup analysis revealed recurrence-free survival at two years in 63.6% of patients with PVNS, 86.7% of those with RA, and 100% of individuals with peripheral spondyloarthritis. Conclusions: This study demonstrates that combined therapy for synovitis is an effective approach, significantly improving clinical outcomes.

show abstract

“…Complicating matters, immunosuppressive medications used to treat SIDs can impede wound healing and increase the risk of joint infection following surgical interventions. The total joint arthroplasty literature has consistently demonstrated a higher rate of complications among patients with inflammatory arthritis compared to those with osteoarthritis [1][2][3][4][5][6][7][8][9]. These concerns have been extrapolated to the field of hip arthroscopy as well, despite a paucity of data on outcomes of hip arthroscopy in patients with SIDs.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Hip Arthroscopy in Patients with Systemic Inflammatory Diseases: A Matched Cohort 5-Year Follow-Up Study

Rynecki,

Shankar,

Morgan

et al. 2023

Surgeries

View full text Add to dashboard Cite

The purpose of this study was to determine if there is a difference in hip survivorship rates and patient-reported outcomes (PROs) at a 5-year follow-up after arthroscopic treatment of femoroacetabular impingement syndrome (FAIS) between patients with versus without systemic inflammatory diseases (SIDs). A retrospective single-surgeon matched cohort study of FAIS patients who underwent hip arthroscopy and had a minimum of a 5-year follow-up was conducted. Subjects with SIDs were matched at a ratio of 2:3 of age and body mass index (BMI) with respect to controls without SIDs. Subjects completed the modified Harris Hip Score (mHHS) and Non-Arthritic Hip Score (NAHS) prior to surgery and at a 2-year and 5-year follow-up. Survival distributions for time to reoperation and to total hip arthroplasty (THA) were compared between groups using the log-rank test. Fifteen subjects with SIDs (mean age 41.5 years) were matched with twenty-five controls (41.8 years). There were no significant differences in reoperation rates (SIDs 27% vs. controls 20%, p = 0.71) or THA conversion rates (SIDs 7% vs. controls 12%, p = 1.00) at the 5-year follow-up, nor were there differences in survival distributions for reoperations (p = 0.72) or THAs (p = 0.55). There were no significant differences in postoperative mHHS (SIDs 79.3 vs. controls 88.5, p = 0.09) or NAHS (SIDs 82.7 vs. controls 89.3, p = 0.77) by the 5-year follow-up. At the 5-year follow-up, FAIS patients with comorbid SIDs experienced a significant clinical improvement from hip arthroscopy that is comparable to that of FAIS patients without SIDs.

show abstract

Arthroscopic synovectomy of the knee in rheumatoid arthritis defined by the 2010 ACR/EULAR criteria

Cited by 9 publications

References 28 publications

Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling

Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling

Recurrence-Free Survival after Synovectomy and Subsequent Radiosynoviorthesis in Patients with Synovitis of the Knee—A Retrospective Data Analysis

Outcomes of Hip Arthroscopy in Patients with Systemic Inflammatory Diseases: A Matched Cohort 5-Year Follow-Up Study

Contact Info

Product

Resources

About