Background/Aim: Osteoarthritis is one of the most common degenerative conditions that causes pain, stiffness, and decreased functionality. The management of knee osteoarthritis necessitates collaboration among specialists from different disciplines, considering the primary clinical manifestations and functional level of the disease. The aim of this study was to highlight the disparities in postoperative outcomes between knee arthroplasty procedures with and without non-steroidal anti-inflammatory drugs (NSAIDs). The study specifically focuses on the immediate advantages and outcomes observed at the 6month milestone. Patients and Methods: This study followed 713 patients who were randomly divided into two groups: a group that did not receive non-steroidal anti-inflammatory drugs (N-NSAIDs) consisting of 394 patients, and a group that received non-steroidal anti-inflammatory drugs (NSAIDs) comprising 319 patients. The study spanned a duration of 5 years (2018)(2019)(2020)(2021)(2022), with patients being followed and evaluated for up to 6 months after the surgery. Results: It was observed that, from a therapeutic standpoint, the use of injectable treatments decreased. Significantly better differences were recorded in the N-NSAIDs group regarding return to pre-osteoarthritis activities at 6 months and reduced or absent night pain at 3 months (p<0.05). Conclusion: Statistically significant improvements were observed in the N-NSAIDs group concerning the ability to resume pre-osteoarthritis activities within 6 months, as well as a reduction or absence of nighttime pain within 3 months. Knee osteoarthritis, the most common form of arthritis, is increasingly prevalent as individuals age and obesity rates rise. Recent studies report an incidence of 10% in men and 13% in women aged 60 years or older, with this rate tripling among patients over 70 years of age. Women are more commonly affected by knee osteoarthritis, although not all cases exhibit evident symptoms on radiographs. Only 15% of individuals with X-ray evidence of knee osteoarthritis experience symptoms, highlighting the disparity (1, 2). Symptomatic knee osteoarthritis is estimated to occur at a rate of approximately 240 cases per 100,000 people annually, irrespective of age (3,4).The symptoms of knee osteoarthritis can vary depending on the underlying cause. The most prevalent symptom is pain around the knee joint, which can be dull, sharp, constant, or intermittent and may worsen with certain activities. The intensity of pain ranges from mild to extremely severe (5). Reduced joint mobility, accompanied by audible grinding or popping sounds, is often observed (6). Swelling, locking, and knee instability are also common symptoms. These pain-related issues frequently limit walking ability, climbing stairs, performing household tasks, and standing, resulting in a negative impact on quality of life and potentially leading to psychological distress (7, 8).The structure of articular cartilage comprises proteoglycans, type II collagen, water, and chondrocytes (9, 10)...