Arthroscopic Resection of Fat Pad Lesions and Infrapatellar Contractures

Doner, Geoffrey P.; Noyes, Frank R.

doi:10.1016/j.eats.2014.04.002

Cited by 21 publications

(17 citation statements)

References 8 publications

(13 reference statements)

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“…IPFP is routinely removed as surgical waste during knee arthroplasty, and it represents an accessible source of ASCs. In 1904, Hoffa described the surgical removal of IPFP, and after that Kumar mentioned an arthroscopic technique to ablate IPFP in 2007 17) . In brief, for the isolation of the IPFP during knee arthroplasty in our clinical setting, the tourniquet was inflated and then limited medial parapatellar skin incision (ca.…”

Section: Isolation and Characterizationmentioning

confidence: 99%

Infrapatellar Fat Pad-Derived Stem Cell-Based Regenerative Strategies in Orthopedic Surgery

Huri

Hamsici

Ergene

et al. 2018

Knee Surg Relat Res

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Infrapatellar fat pad is a densely vascularized and innervated extrasynovial tissue that fills the anterior knee compartment. It plays a role in knee biomechanics as well as constitutes a source of stem cells for regeneration after knee injury. Infrapatellar fat pad-derived stem cells (IPFP-ASCs) possess enhanced and age-independent differentiation capacity as compared to other stem cells, which makes them a very promising candidate in stem cell-based regenerative therapy. The aims of this review are to outline the latest advances and potential trends in using IPFP-ASCs and to emphasize the advantages over other sources of stem cells for applications in orthopedic surgery.

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Section: Isolation and Characterizationmentioning

confidence: 99%

Infrapatellar Fat Pad-Derived Stem Cell-Based Regenerative Strategies in Orthopedic Surgery

Huri

Hamsici

Ergene

et al. 2018

Knee Surg Relat Res

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“…In order to put forward the IFP as a promising cell source for cartilage regeneration, it is important to understand its anatomical characteristics, as well as its developmental origin. As an adipose tissue within the joint, the IFP can be easily harvested arthroscopically or during open knee surgery [ 38 ]. The IFP is an intracapsular structure in the anterior knee compartment, composed of approximately 20 cm 3 of adipose tissue, or slightly larger in patellofemoral OA joints [ 39 – 41 ].…”

Section: The Ifp Structure and Developmentmentioning

confidence: 99%

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy

Amaral

Almeida

Kelly

et al. 2017

Stem Cells International

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The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. There are several cell sources being investigated to promote cartilage regeneration: mature articular chondrocytes, chondrocyte progenitors, and various stem cells. Most recently, stem cells isolated from joint tissue, such as chondrogenic stem/progenitors from cartilage itself, synovial fluid, synovial membrane, and infrapatellar fat pad (IFP) have gained great attention due to their increased chondrogenic capacity over the bone marrow and subcutaneous adipose-derived stem cells. In this review, we first describe the IFP anatomy and compare and contrast it with other adipose tissues, with a particular focus on the embryological and developmental aspects of the tissue. We then discuss the recent advances in IFP stem cells for regenerative medicine. We compare their properties with other stem cell types and discuss an ontogeny relationship with other joint cells and their role on in vivo cartilage repair. We conclude with a perspective for future clinical trials using IFP stem cells.

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“…The infrapatellar fat pad (IPFP) is located in the knee joint [ 25 , 26 ]. IPFP can be easily resected during knee surgery either open or arthroscopically [ 27 ]. The isolation of MSCs has previously been reported from this source [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Infrapatellar Fat Pad: An Alternative Source of Adipose-Derived Mesenchymal Stem Cells

et al. 2016

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Introduction. The Infrapatellar fat pad (IPFP) represents an emerging alternative source of adipose-derived mesenchymal stem cells (ASCs). We compared the characteristics and differentiation capacity of ASCs isolated from IPFP and SC. Materials and Methods. ASCs were harvested from either IPFP or SC. IPFPs were collected from patients undergoing total knee arthroplasty (TKA), whereas subcutaneous tissues were collected from patients undergoing lipoaspiration. Immunophenotypes of surface antigens were evaluated. Their ability to form colony-forming units (CFUs) and their differentiation potential were determined. The ASCs karyotype was evaluated. Results. There was no difference in the number of CFUs and size of CFUs between IPFP and SC sources. ASCs isolated from both sources had a normal karyotype. The mesenchymal stem cells (MSCs) markers on flow cytometry was equivalent. IPFP-ASCs demonstrated significantly higher expression of SOX-9 and RUNX-2 over ASCs isolated from SC (6.19 ± 5.56-, 0.47 ± 0.62-fold; p value = 0.047, and 17.33 ± 10.80-, 1.56 ± 1.31-fold; p value = 0.030, resp.). Discussion and Conclusion. CFU assay of IPFP-ASCs and SC-ASCs harvested by lipoaspiration technique was equivalent. The expression of key chondrogenic and osteogenic genes was increased in cells isolated from IPFP. IPFP should be considered a high quality alternative source of ASCs.

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Arthroscopic Resection of Fat Pad Lesions and Infrapatellar Contractures

Cited by 21 publications

References 8 publications

Infrapatellar Fat Pad-Derived Stem Cell-Based Regenerative Strategies in Orthopedic Surgery

Infrapatellar Fat Pad-Derived Stem Cell-Based Regenerative Strategies in Orthopedic Surgery

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy

Infrapatellar Fat Pad: An Alternative Source of Adipose-Derived Mesenchymal Stem Cells

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