Arthroscopic Harvest of Adipose-Derived Mesenchymal Stem Cells From the Infrapatellar Fat Pad

Dragoo, Jason L.; Chang, Wenteh

doi:10.1177/0363546517719454

Cited by 47 publications

(65 citation statements)

References 53 publications

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“…ASCs are another popular type of adult stem cells due to the ease of harvesting and the large quantity of adipose tissue available from subcutaneous fat or infrapatellar fat pad during liposuction or orthopedic procedures, respectively. 153,154 Their efficacy in skeletal tissue repair has been established, but their specific impact on long bone versus calvarial bone healing has not been identified.…”

Section: Stem Cell-based Therapymentioning

confidence: 99%

Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering

Wang

Gilbert

Zhang

et al. 2020

Tissue Engineering Part B: Reviews

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Tissue-engineered graft substitutes have shown great potential to treat large bone defects. While we usually assume that therapeutic approaches developed for appendicular bone healing could be similarly translated for application in craniofacial reconstruction and vice versa, this is not necessarily accurate. In addition to those more well-known healing-associated factors, such as age, lifestyle (e.g., nutrition and smoking), preexisting disease (e.g., diabetes), medication, and poor blood supply, the developmental origins and surrounding tissue of the wound sites can largely affect the fracture healing outcome as well as designed treatments. Therefore, the strategies developed for long bone fracture repair might not be suitable or directly applicable to skull bone repair. In this review, we discuss aspects of development, healing process, structure, and tissue engineering considerations between calvarial and long bones to assist in designing the tailored bone repair strategies.

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Section: Stem Cell-based Therapymentioning

confidence: 99%

Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering

Wang

Gilbert

Zhang

et al. 2020

Tissue Engineering Part B: Reviews

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“…6 ml of 0.9% saline was used to mix the lipoaspirate to make cell concentrates. 5 ml of the cell concentrates were injected into the corresponding joint cavity, and another 1 ml were was used for identi cation by ow cytometry [23] and being cultured to see if the cell concentrates were contaminated.…”

Section: Interventionsmentioning

confidence: 99%

Clinical Efficacy of Arthroscopic Therapy With Infrapatellar Fat Pad Cell Concentrates in Treating Knee Cartilage Lesion: a Randomized Controlled Trial

Zhou¹,

Li²,

Dong³

et al. 2020

Preprint

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Background: Toevaluatethe clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesion, we launched a prospective randomized single-blind clinical study of controlled method.Methods: 60 cases from Shanghai Changzheng Hospital during April 2018 to December 2019 were chosen and randomlydivided into 2 groups equally. Patients in the experiment group were treated throughknee arthroscopy with knee infrapatellar fat pad cell concentrates containing mesenchymal stem cells, while patients in the control group were treated through regular knee arthroscopic therapy. VAS and WOMAC scores were assessed at pre-operation, and 6 weeks, 12 weeks, 6 months, 12 months after intervention. MORCART scores were assessed at pre-operation and 12 months after intervention.Results: 29 cases in the experiment group and 28 cases in the control group were followed up. No significant difference in VAS, WOMAC, and MOCART scores were found between the two groups before surgery(P>0.05). The WOMAC-Total and WOMAC-Function scores ofexperiment groupwere significantly lower than those of control group 6 months, 12 months after surgery(P<0.05). The VAS-Rest and VAS-Motion scoresofexperiment group were found significantly lower than those of control group 12 months after surgery(P<0.05).The MOCART scores of experiment group were found significant higher compared with control group12 months after surgery(P<0.05). No significant difference in WOMAC-Stiffness scores were found between the two groups.Conclusions:The short-term results of our study are encouraging and demonstrate that knee arthroscopy with infrapatellar fat pad cell concentrates containing mesenchymal stem cells is safe, and provides assistance in reducing pain and improvingfunction in patients with knee cartilage lesion.Trial registration: ChiCTR1800015379. Registered on 27 March 2018, http://www.chictr.org.cn/showproj.aspx?proj=25901.

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“…Interestingly, nucleofected bone marrow‐derived stem cells showed a greater osteogenic potential than adipose‐derived stem cells. However, adipose tissue remains one of the most attractive cell sources for regenerative medicine and, of interest for the field of orthopedics, multipotent adipose‐derived stem cells can be isolated not only from liposuction aspirates, but also from the infrapatellar fat pad of the knee …”

Section: Conventional Ex Vivo Gene Therapymentioning

confidence: 99%

Recent advances in gene‐enhanced bone tissue engineering

Betz

Kochanek

Rammelt

et al. 2018

The Journal of Gene Medicine

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The loss of bone tissue represents a critical clinical condition that is frequently faced by surgeons. Substantial progress has been made in the area of bone research, providing insight into the biology of bone under physiological and pathological conditions, as well as tools for the stimulation of bone regeneration. The present review discusses recent advances in the field of gene-enhanced bone tissue engineering. Gene transfer strategies have emerged as highly effective tissue engineering approaches for supporting the repair of the musculoskeletal system. By contrast to treatment with recombinant proteins, genetically engineered cells can release growth factors at the site of injury over extended periods of time. Of particular interest are the expedited technologies that can be applied during a single surgical procedure in a cost-effective manner, allowing translation from bench to bedside. Several promising methods based on the intra-operative genetic manipulation of autologous cells or tissue fragments have been developed in preclinical studies. Moreover, gene therapy for bone regeneration has entered the clinical stage with clinical trials for the repair of alveolar bone. Current trends in gene-enhanced bone engineering are also discussed with respect to the movement of the field towards expedited, translational approaches. It is possible that gene-enhanced bone tissue engineering will become a clinical reality within the next few years.

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Arthroscopic Harvest of Adipose-Derived Mesenchymal Stem Cells From the Infrapatellar Fat Pad

Abstract: An autologous source of stem cells can now be harvested using a simple arthroscopic technique that will allow orthopaedic surgeons easier access to progenitor cells for regenerative procedures.

Cited by 47 publications

References 53 publications

Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering

Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering

Clinical Efficacy of Arthroscopic Therapy With Infrapatellar Fat Pad Cell Concentrates in Treating Knee Cartilage Lesion: a Randomized Controlled Trial

Recent advances in gene‐enhanced bone tissue engineering

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