Arthroscopic Collagen Meniscus Implantation for Partial Lateral Meniscal Defects

Abstract

The lateral CMI demonstrated that it was safe in this population study, with decreased pain and improved knee function in 96% of patients with excellent/good Lysholm results in 87% of patients at a minimum 2-year follow-up. The MRI scans demonstrated a decreased implant size relative to a normal meniscus.

Meniscus Reconstruction Using a New Collagen Meniscus Implant

“…A recent systematic review reported that satisfactory outcomes are achieved in approximately 70 % of patients treated with CMI (Harston et al 2011), while 30 % did not receive any benefit; this is in contrast with studies that reported good/excellent results in more than 90 % of patients (Zaffagnini et al 2012). The cornerstone study of CMI surgery is the randomized controlled trial performed by Rodkey et al (2008), which compared medial CMI to medial meniscectomy at 5 years' follow-up.…”

“…Regarding acute meniscal lesion, no significant difference was found compared with the control group, thus limiting the indication of CMI to patients with previous meniscectomy. As the lateral CMI was developed more than 10 years after the medial CMI, there are few reports in the current literature on the results of the lateral procedures (Zaffagnini et al 2011b(Zaffagnini et al , 2012Hirschmann et al 2013). Outcomes similar to those of the medial CMI have been reported , even if no randomized controlled trials or long-term follow-up studies are yet available.…”

“…However, this process, which suggests implant maturation, appears to be almost complete in only a small percentage of implants. In fact, most devices assume a signal that is slightly hyperintense compared to the native meniscus, and which is more similar to the newly implanted scaffold (Bulgheroni et al 2010;Monllau et al 2011;Zaffagnini et al 2011Zaffagnini et al , 2012. …”

Triggering Cell–Biomaterial Interaction: Recent Approaches for Osteochondral Regeneration

“…The evaluation was performed from basal level up to 10 years of follow-up, using clinical scores IKDC, VAS, and SF-36, and radiological images. The results showed a significant improvement in all scores and fewer signs of degeneration at the radiological evaluation in the CMI group [28,29]. Kon et al published a study of 18 patients who required partial meniscectomy, affected by partial meniscal tears or patients with a chronic loss of meniscal tissue, treated by arthroscopic polyurethane meniscal scaffold implantation (Actifit ® , Orteq Sports Medicine, London, UK).…”

What’s New in Orthopaedic Research

“…Data from the Rizzoli Orthopaedic Institute demonstrated that implantation of Actifit (Orteq BioEngineering) in eighteen patients, with thirteen implants in the medial meniscus and five in the lateral meniscus, resulted in significant increases in the International Knee Documentation Committee (IKDC) and Tegner scores at two years postoperatively as compared with those at baseline 44 . Zaffagnini et al demonstrated that implantation of the collagen meniscus implant (CMI; Ivy Sport Medicine, Montvale, New Jersey) in the lateral meniscus resulted in decreased pain and improved knee function in 96% of patients at a minimum of two years of follow-up; however, 87% of implants were reduced in size relative to that of the normal meniscus, indicating shrinkage of the implant 45 . While the underlying cause of this geometric discrepancy is unclear, such changes are likely to threaten scaffold-tissue integration.…”