Arthrodesis after workplace injuries

The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study

“…Inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β, can promote cartilage breakdown, induce synovial changes, and inhibit repair mechanisms, thereby increasing the risk of OA ( 31 ). Fourth, many jobs involving heavy physical labor often do not provide sufficient rest and recovery time for the musculoskeletal system ( 25 ). The absence of adequate rest intervals during continuous exertion may impede the proper repair and reconstruction of tissues, which can negatively affect the health of joint structures, increasing their susceptibility to degeneration and OA.…”

“…The joints can experience heightened stress and strain on the articular cartilage when subjected to repetitive or excessive loading, such as heavy lifting or carrying, which may ultimately result in cartilage degradation and the development of OA over time. Second, job involves heavy manual or physical work often involves a higher risk of joint injuries and microtrauma (25)(26)(27)(28). Acute injuries, such as fractures or ligament tears, can disrupt normal joint mechanics and increase the likelihood of developing OA later in life.…”