Arthritis Prediction of Advanced Hepatic Fibrosis in HFE Hemochromatosis

Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver

“…A recent study showed that arthritis was strongly associated with advanced liver fibrosis, and 84% of HFE p.Cys282Tyr homozygous subjects with advanced hepatic fibrosis had arthritis, while 34% p.Cys282Tyr homozygotes with arthritis had advanced hepatic fibrosis. Importantly, only 5% of subjects without arthritis had advanced hepatic fibrosis; thus, the absence of arthritis had a 95% negative predictive value for advanced liver fibrosis [ 57 ].…”

“…In HFE-hemochromatosis, liver disease and arthritis can occur concurrently [ 95 ], with arthritis more likely in patients with higher body iron load and/or advanced hepatic fibrosis [ 67 , 68 ]. Arthritis was recently shown to be strongly associated with the presence of advanced fibrosis, with 84% of patients with advanced fibrosis also having arthritis [ 57 ]. Of interest, the absence of arthritis had a 95% negative predictive value for advanced fibrosis [ 57 ].…”

“…Arthritis was recently shown to be strongly associated with the presence of advanced fibrosis, with 84% of patients with advanced fibrosis also having arthritis [ 57 ]. Of interest, the absence of arthritis had a 95% negative predictive value for advanced fibrosis [ 57 ].…”

Hemocromatosis hereditaria

“…Se ha descripto con una prevalencia que oscila entre 10% y 86,5%. [22][23] En nuestra serie la hemos observado en el 24% de los casos. Como fue mencionado, la artritis se ha reportado entre los factores asociados a HH con fibrosis hepática avanzada.…”