Arthritis possibly induced and exacerbated by a tumour necrosis factor antagonist in a patient with psoriasis vulgaris

Safety of biologics in psoriasis

“…Takahashi et al . reported a case of a psoriatic patient in whom adalimumab treatment possibly induced new‐onset arthritis, successfully treated with ustekinumab.…”

“…Skin lesions of paradoxical reaction typically do not require therapy cessation unless they are severe and intolerable lesions or patients prefer discontinuation of TNF-a inhibitors. 26 Takahashi et al 36 reported a case of a psoriatic patient in whom adalimumab treatment possibly induced new-onset arthritis, successfully treated with ustekinumab. This case could be a paradoxical reaction of adalimumab, although the mechanism is unknown.…”

Development of paradoxical inflammatory disorders during treatment of psoriasis with TNF inhibitors: a review of published cases

“…24 New onset or exacerbation of psoriatic arthritis was described by Sanchez et al 23 in 30 patients among 620 treated with either infliximab or etanercept. Two cases resulting from adalimumab were found, 25,26 in which a 71-year-old man who developed psoriatic arthritis after 3 months of treatment of psoriasis vulgaris was mentioned.…”

“…Two cases resulting from adalimumab were found,25,26 in which a 71-year-old man who developed psoriatic arthritis after 3 months of treatment of psoriasis vulgaris was mentioned.A total of seven clinical trials7,8,[27][28][29][30][31] and four case reports 32-35 described a lupus-like syndrome, drug-induced lupus, or systemic lupus erythematosus. Two cases resulting from adalimumab were found,25,26 in which a 71-year-old man who developed psoriatic arthritis after 3 months of treatment of psoriasis vulgaris was mentioned.A total of seven clinical trials7,8,[27][28][29][30][31] and four case reports 32-35 described a lupus-like syndrome, drug-induced lupus, or systemic lupus erythematosus.…”

Triple paradoxical reaction due to adalimumab

“…Two cases reported explain the onset of inflammatory polyarthritis during adalimumab therapy. 7,8 Other authors suggest infliximab could trigger new arthritis in patients with hidradenitis suppurativa. 9 However, only one case of paradoxical psoriatic arthritis in a patient with RA has been reported.…”