Arthritis Induced by Adjuvant in Spontaneously Hypertensive and Normotensive Rats: Endogenous Glucocorticoid Effects on Inflammatory Response

Torres, Maricy Morbin; Kwasniewski, Fábio Henrique; Scaliante, Luís G.; Ishii–Iwamoto, Emy Luiza; Caparroz-Assef, Silvana Martins; Cuman, Roberto Kenji Nakamura; Bersani-Amado, Ciomar Aparecida

doi:10.1007/s10753-008-9098-7

Cited by 4 publications

(2 citation statements)

References 23 publications

(34 reference statements)

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“…The development of systemic manifestations of AIA involves the appearance of secondary polyarthritis, an increase in lymph node weight, and a decrease in body weight [28]. Because we observed an insignificant increase in the body weight of the arthritis group treated with FHPp, but observed decreased levels of glucose, cholesterol, and triglycerides, the animals were placed in metabolism cages to evaluate whether these effects were the result of metabolic changes or differences in water and food intake.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits ofPterodon pubescensBenth in Acute and Chronic Inflammation

Hoscheid

Bersani-Amado

Rocha

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Fruits of Pterodon pubescens Benth have been used traditionally for the treatment of rheumatism, sore throat, and respiratory disorders, and also as anti-inflammatory, analgesic, depurative, tonic, and hypoglycemic agent. The study was aimed at evaluating the anti-inflammatory activity of the hexane fraction of an ethanolic extract of P. pubescens fruits. The oil from P. pubescens fruits was extracted with ethanol and partitioned with hexane. The anti-inflammatory activity was measured with increasing doses of the hexane fraction (FHPp) by using a carrageenan-induced rat model of pleurisy and a rat model of complete Freund's adjuvant-induced arthritis by using an FHPp dose of 250 mg/kg for 21 days. Treatment with an FHPp resulted in anti-inflammatory activity in both models. The results of biochemical, hematological, and histological analyses indicated a significant decrease in glucose, cholesterol, and triglycerides levels (18.32%, 34.20%, and 41.70%, resp.) and reduction in the numbers of total leukocytes and mononuclear cells. The FHPp dose of 1000 mg/kg induced no changes in behavioral parameters, and no animal died. The results of this study extend the findings of previous reports that have shown that administration of extracts and fractions obtained from species of the genus Pterodon exhibits anti-inflammatory activity and lacks toxicity.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits ofPterodon pubescensBenth in Acute and Chronic Inflammation

Hoscheid

Bersani-Amado

Rocha

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Moreover, absence of CORT for 3 days due to adrenalectomy (ADX) can result in apoptosis of granule cells of the dentate gyrus (DG) in adult rats (Greiner et al, 2001). Reduction of CORT in ad libitum fed rats by ADX produced hypophagia and satiety (Torres et al, 2008) and decreased locomotor activity (Duclos et al, 2009). By contrast, administration of these substances as steroids results in hyperphagia in humans (Tataranni et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids

Qiu

Spangler

Wan

et al. 2012

Neurobiology of Aging

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Glucocorticoids (GC)--corticosterone (CORT) in rodents and cortisol in primates--are stress-induced hormones secreted by adrenal glands that interact with the hypothalamic pituitary axis. High levels of cortisol in humans are observed in neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), as well as in diabetes, post-traumatic stress syndrome, and major depression. Experimental models of diabetes in rats and mice have demonstrated that reduction of CORT reduces learning and memory deficits and attenuates loss of neuronal viability and plasticity. In contrast to the negative associations of elevated GC levels, CORT is moderately elevated in dietary restriction (DR) paradigms which are associated with many healthy anti-aging effects including neuroprotection. We demonstrate here in rats that ablating CORT by adrenalectomy (ADX) with replenishment to relatively low levels (30% below that of controls) prior to the onset of a DR regimen (ADX-DR) followed by central administration of the neurotoxin, kainic acid (KA), significantly attenuates learning deficits in a 14-unit T-maze task. The performance of the ADX-DR KA group did not differ from a control group (CON) that did not receive KA and was fed ad libitum (AL). By contrast, the sham-operated DR (SHAM-DR KA) group, SHAM-AL KA group, and ADX-AL KA group demonstrated poorer learning behavior in this task compared to the CON group. Stereological analysis revealed equivalent DR-induced neuroprotection in the SH-DR KA and ADX-DR KA groups, as measured by cell loss in the CA2/CA3 region of the hippocampus, while substantial cell loss was observed in SH-AL and ADX-AL rats. A separate set of experiments was conducted with similar dietary and surgical treatment conditions but without KA administration to examine markers of neurotrophic activity, brain-derived neurotrophic factor (BDNF), transcriptions factors (pCREB), and chaperone proteins (HSP-70). Under these conditions, we noted elevations in both BDNF and pCREB in ADX DR rats compared to the other groups; whereas, HSP-70, was equivalently elevated in ADX-DR and SH-DR groups and was higher than observed in both SH-AL and ADX-AL groups. These results support findings that DR protects hippocampal neurons against KA-induced cellular insult. However, this neuroprotective effect was further enhanced in rats with a lower-than control level of CORT resulting from ADX and maintained by exogenous CORT supplementation. Our results then suggest that DR-induced physiological elevation of GC may have negative functional consequences to DR-induced beneficial effects. These negative effects, however, can be compensated by other DR-produced cellular and molecular protective mechanisms.

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Does Chronic Pain Alter the Normal Interaction Between Cardiovascular and Pain Regulatory Systems? Pain Modulation in the Hypertensive-Monoarthritic Rat

Pinho

Morato

Couto

et al. 2011

The Journal of Pain

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Arthritis Induced by Adjuvant in Spontaneously Hypertensive and Normotensive Rats: Endogenous Glucocorticoid Effects on Inflammatory Response

Cited by 4 publications

References 23 publications

Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits ofPterodon pubescensBenth in Acute and Chronic Inflammation

Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits ofPterodon pubescensBenth in Acute and Chronic Inflammation

Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids

Does Chronic Pain Alter the Normal Interaction Between Cardiovascular and Pain Regulatory Systems? Pain Modulation in the Hypertensive-Monoarthritic Rat

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