Arthritis in idiopathic hypereosinophilic syndrome

Martían-Santo71s, J. Manuel; Mulero, Juan; Andréau, J. Luis; Villa, L. F.; Quiróas, Luis Bernaldo-De; Noguera, Enrique

doi:10.1002/art.1780310117

Cited by 25 publications

(4 citation statements)

References 9 publications

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“…Martin-Santos et al reported a non-erosive arthropathy with tenosynovitis. 5 Tay CH also reported 10 cases with eosinophilic large joint arthritis of unknown etiology but none had HES. 6 Risk of infection is not high in HES, which explains the culture negative purulent synovitis in this patient; and the high synovial fluid white cells with elevated eosinophils could merely be a representation of a massively high blood leucocytosis and eosinophilia extravasating into the synovial fluid.…”

Section: Discussionmentioning

confidence: 99%

“…Synovial fluid eosinophilia has also been reported in the past. 2,5 Virtually, any organ system may be involved in HES, but the heart, central nervous system, skin, and respiratory tract are commonly involved. Cardiovascular complications of HES are a major source of morbidity and mortality with reported frequency of 40-50%.…”

Section: Discussionmentioning

confidence: 99%

“…4 Reports on initial rheumatologic manifestations in patients with HES are very rare. 5,6 Here, we present an unusual case of purulent polyarthritis as the first presentation of HES.…”

Section: Introductionmentioning

confidence: 95%

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Polyarthritis as the Initial Presentation of Hyper Eosinophilic Syndrome

Nazir

Riaz

Alam

2019

J Coll Physicians Surg Pak

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Hyper eosinophilic syndrome (HES) is a rare condition with a potential for morbidity and mortality, if left untreated. Therefore, it is important to highlight it, as often these cases are misdiagnosed and mismanaged, specially when presenting with an atypical initial presentation. This case report describes an unusual initial clinical presentation of HES. Patient was a 75-year lady presenting to Rheumatology Clinic with short duration of fever and polyarthritis. Joint aspiration showed purulent fluid with a cell count of 61,000/mm 3 with predominant neutrophils and eosinophils. Her peripheral blood also showed a high white blood cell (WBC) count (80,700/mm 3 with 73% eosinophils). Her workup for eosinophilic leukemia was negative, so a diagnosis of HES was made. She was initiated on corticosteroids and hydroxycarbamide as first-line therapy. Unfortunately, the patient was unresponsive to steroids with her WBC count rising to 130,000/mm 3 and her clinical course was complicated by cardiac failure and peripheral neuropathy. Improvement in arthritis and peripheral eosinophilia was noted after she was given imatinib and stabilised clinically.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Polyarthritis as the Initial Presentation of Hyper Eosinophilic Syndrome

Nazir

Riaz

Alam

2019

J Coll Physicians Surg Pak

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“…Worldwide, parasitic diseases are the most common cause, whereas in developed countries, allergic diseases are the most common cause [7]. Although rheumatologic manifestations of HES are infrequent, several previous reports showed HES association with an inflammatory joint disease mimicking RA [3,[8][9][10]. Furthermore, Tay [11] described 10 patients from Singapore with acute polyarthritis and marked hypereosinophilia of unknown etiology.…”

Section: Discussionmentioning

confidence: 99%

Hypereosinophilic Syndrome Associated with the Onset of Rheumatoid Arthritis: A Case Report

et al. 2017

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Idiopathic hypereosinophilic syndrome (HES) is a disorder characterized by the sustained overproduction of eosinophils and multiple organ damage. Rheumatologic manifestations of HES are infrequent, but persistent eosinophilia is observed in approximately 10% to 40% of patients with rheumatoid arthritis (RA). This finding may be a result of the RA itself and is often associated with active disease and the presence of extra-articular features. We describe the case of a 48-year-old man affected by HES who subsequently developed RA. Both HES and RA responded rapidly to the corticosteroid and methotrexate therapy. In this patient, the initiation of RA and HES was related, suggesting a common pathogenetic link between these two diseases. (J Rheum Dis 2017;24:165-168)

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Antibodies to the collagen‐like region of C1q in sera of patients with autoimmune rheumatic diseases

Wener

Uwatoko

Mannik

1989

Arthritis & Rheumatism

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Antibodies to the collagen‐like region of C1q have recently been observed in sera of patients with systemic lupus erythematosus (SLE). In this study, we documented that these antibodies were present in 47.3% of SLE patient sera, whereas they were uncommon in sera from patients with rheumatoid arthritis (2.8%) and Sjögren's syndrome (12.8%), as well as in normal sera (6.4%). Markedly elevated antibody levels (>4 SD above the normal mean) were observed almost exclusively in sera of patients with SLE. Levels of antibodies to the collagen‐like region correlated highly with levels of solid‐phase C1q‐binding IgG when analyzed by the C1q solid‐phase assay for immune complexes (r = 0.87). We previously found that, after sucrose density gradient ultracentrifugation, a predominance of the solid‐phase C1q‐binding IgG in SLE sera sediments as monomeric IgG. These findings, together with the present data, indicate that reactivity of SLE patients' sera in the C1q solid‐phase assay reflects primarily the presence of antibodies to the collagen‐like region, and not the presence of immune complexes.

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Arthritis in idiopathic hypereosinophilic syndrome

Cited by 25 publications

References 9 publications

Polyarthritis as the Initial Presentation of Hyper Eosinophilic Syndrome

Polyarthritis as the Initial Presentation of Hyper Eosinophilic Syndrome

Hypereosinophilic Syndrome Associated with the Onset of Rheumatoid Arthritis: A Case Report

Antibodies to the collagen‐like region of C1q in sera of patients with autoimmune rheumatic diseases

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