Arthritis in cystic fibrosis.

Abstract

Cushing's syndrome and bronchial carcinoid tumour 377 costeroids are unaffected by high dose dexamethasone and metyrapone.In our patient, the adrenal function tests were so consistent with pituitary disease that the pulmonary lesion was initially thought to be coincidental. However, the resolution of hypercortisolism after excision of a tumour, known in adults3 to be associated with the ectopic adrenocorticotrophic hormone syndrome, and the finding of adrenocorticotrophic hormone and related peptides in the tumour, confirmed the diagnosis of ectopic adrenocorticotrophic hormone secretion.Serum

Cutaneous Manifestations of Cystic Fibrosis

“…Infectious agents, medications, and the use of pancreatic supplements in those with CF provide a ready source of antigens for formation of immune complexes. The deposition of immune complexes can result in secondary cutaneous vasculitis (21)(22)(23)(24)(25)(26)(27)(28).…”

“…Cutaneous vasculitis has been reported in CF patients, and may be associated with joint (i.e., arthralgias) (21)(22)(23)(24)(25)(26)(27)(28), neurologic, and renal involvement (26,61). It has been proposed that vascular damage may occur via immunologic mechanisms with deposition of immune complexes in the vascular wall (21).…”

“…Vasculitic lesions tend to be located on the lower extremities (21)(22)(23). Intermittent arthralgias may be present (21,27,28). These dermatologic manifestations have been reported to occur in association with an exacerbation of pulmonary symptoms (21).…”

Cistinės Fibrozės Artropatijos: Klinikinis Atvejis

“…Daž-niausiai šie simptomai išnyksta savaime, nors pasitaiko ir besikartojančių atkryčio atvejų, trunkančių savaites ar net metus. Kartais su artralgija pastebimas sąnarių patinimas, funkcijos sutrikimas, gali atsirasti ir karščiavimas bei odos bėrimas, panašus į mazginę ertitemą [4,8,12,14]. Artritas būna neerozinis, reumatoidinis faktorius neigiamas, radiologiniais tyrimais jokių sąnarių pažeidimų nenustatoma.…”

Rheumatic disease and cystic fibrosis

“…The majority of reported patients are negative for both serum rheumatoid factor and antinuclear antibodies (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(15)(16)(17). Abnormal immunoglobulin levels have been found in patients with CFA (1,4,5,10,15,16), but this also occurs in patients with CF without arthropathy (18).…”