Arthrite septique sternoclaviculaire à Kingella kingae chez un adulte

Ricard, E.; Martin, Carine; Bertin, Philippe; Denès, E.

doi:10.1016/j.medmal.2013.12.005

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…However, the metacarpophalangeal, sternoclavicular, tarsal, and sacro-iliac joints (148,(170)(171)(172)(173), which are rarely affected by other bacterial species, are involved with unusual frequency in K. kingae arthritis (18). Involvement of two joints was observed in 8 of 140 (5.7%) children with K. kingae suppurative arthritis (102), a proportion comparable to that found in infections induced by traditional pathogens (174).…”

Section: Skeletal System Infectionsmentioning

confidence: 96%

“…The sensitivity of cultures can be significantly enhanced by inoculating synovial fluid aspirates into aerobic BCVs from commercial systems such as Bactec (17,289), BacT/Alert (173,(290)(291)(292), Hémoline DUO (129,293), Isolator 1.5 Microbial Tube (175), and in-house-made liquid media (294). In a pioneer study, K. kingae was detected in 25 synovial fluid specimens seeded into aerobic Bactec bottles after an average of 4 days, whereas the accompanying culture plates recovered the organism in only two cases (17).…”

Section: Detection By Culturementioning

confidence: 99%

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Kingella kingae: Carriage, Transmission, and Disease

2015

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SUMMARY Kingella kingae is a common etiology of pediatric bacteremia and the leading agent of osteomyelitis and septic arthritis in children aged 6 to 36 months. This Gram-negative bacterium is carried asymptomatically in the oropharynx and disseminates by close interpersonal contact. The colonized epithelium is the source of bloodstream invasion and dissemination to distant sites, and certain clones show significant association with bacteremia, osteoarthritis, or endocarditis. Kingella kingae produces an RTX (repeat-in-toxin) toxin with broad-spectrum cytotoxicity that probably facilitates mucosal colonization and persistence of the organism in the bloodstream and deep body tissues. With the exception of patients with endocardial involvement, children with K. kingae diseases often show only mild symptoms and signs, necessitating clinical acumen. The isolation of K. kingae on routine solid media is suboptimal, and detection of the bacterium is significantly improved by inoculating exudates into blood culture bottles and the use of PCR-based assays. The organism is generally susceptible to antibiotics that are administered to young patients with joint and bone infections. β-Lactamase production is clonal, and the local prevalence of β-lactamase-producing strains is variable. If adequately and promptly treated, invasive K. kingae infections with no endocardial involvement usually run a benign clinical course.

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Section: Skeletal System Infectionsmentioning

confidence: 96%

Section: Detection By Culturementioning

confidence: 99%

Kingella kingae: Carriage, Transmission, and Disease

2015

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“…Following an extensive literature review, we identified only 7 case reports of septic arthritis in adults [ 10 , 12 – 16 ]. There was only one reported case of isolated infection in an otherwise immunocompetent adult; this also affected the knee [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Kingella kingaeCausing Septic Arthritis of the Knee in anImmunocompetentAdult

Ricketts

Rehmatullah

Sutton

2015

Case Reports in Orthopedics

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The bacterium Kingella kingae is a species of Gram-negative coccobacillus usually found in the oropharynx. This is an emerging pathogen reported to cause bacteraemia, endocarditis, and osteoarticular infections in children and endocarditis in the immunocompromised adult. However, there are few cases of isolated joint infections reported in the immunocompetent adult. Due to specific isolation techniques required, delay in diagnosis can compromise patient outcome. We report a rare case of septic arthritis of the knee in an immunocompetent adult caused by K. kingae.

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“…Cultures of joint fluid aspirates and bone biopsy samples in solid media frequently fail to recover Kingella kingae because the growth of the bacterium is inhibited by the presence of leukocytes, complement, antibodies, and eventual antibiotics in the sample [ 11 , 23 , 24 ]. The sensitivity of these cultures can be significantly improved by inoculating them into aerobic BCVs from the automated Bactec [ 11 , 25 ] and BacT/Alert systems (Organon Teknika Corporation, Durham, NC, USA) [ 26 , 27 , 28 , 29 ], the manual Hémoline DUO (bioMérieux, Marcy-l’étoile, France) [ 30 , 31 ] and Isolator 1.5 Microbial Tube (Wampole Laboratories, Cranbury, NJ, USA) [ 32 ] systems, and in-house-made liquid medium [ 33 ]. In a pioneering study, Kingella kingae was recovered in eleven joint fluid aspirates seeded into pediatric aerobic Bactec BCVs.…”

Section: Detectionmentioning

confidence: 99%

The Past, Present, and Future of Kingella kingae Detection in Pediatric Osteoarthritis

Yagupsky¹

2022

Diagnostics

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As a result of the increasing use of improved detection methods, Kingella kingae, a Gram-negative component of the pediatric oropharyngeal microbiota, is increasingly appreciated as the prime etiology of septic arthritis, osteomyelitis, and spondylodiscitis in children aged 6 to 48 months. The medical literature was reviewed to summarize the laboratory methods required for detecting the organism. Kingella kingae is notoriously fastidious, and seeding skeletal system samples onto solid culture media usually fails to isolate it. Inoculation of synovial fluid aspirates and bone exudates into blood culture vials enhances Kingella kingae recovery by diluting detrimental factors in the specimen. The detection of the species has been further improved by nucleic acid amplification tests, especially by using species-specific primers targeting Kingella kingae’s rtxA, groEL, and mdh genes in a real-time PCR platform. Although novel metagenomic next-generation technology performed in the patient’s plasma sample (liquid biopsy) has not yet reached its full potential, improvements in the sensitivity and specificity of the method will probably make this approach the primary means of diagnosing Kingella kingae infections in the future.

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Arthrite septique sternoclaviculaire à Kingella kingae chez un adulte

Cited by 6 publications

References 9 publications

Kingella kingae: Carriage, Transmission, and Disease

Kingella kingae: Carriage, Transmission, and Disease

Kingella kingaeCausing Septic Arthritis of the Knee in anImmunocompetentAdult

The Past, Present, and Future of Kingella kingae Detection in Pediatric Osteoarthritis

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