Arthrite à pneumocoque révélant un myélome

Renou, F.; Gerber, Anne; Moiton, Marie‐Pierre; Ferrándiz, Daniel Álvarez; Yvin, J.-L.

doi:10.1016/j.revmed.2006.11.007

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Indeed, patients with myeloma have a high risk of infection due to an impairment of specific humoral immunity. This phenomenon is linked to the inability to produce specific antibodies due to hypogammaglobulinemia associated with the secretion of a monoclonal protein as in our case [2,6]. Ionizing radiation recognized as a risk factor for multiple myeloma was not identified in our patient.…”

Section: Discussionmentioning

confidence: 63%

“…Pneumococcus is one of the germs frequently found in acute otitis media [9,10]. However, immunity mainly developed against Pneumococcus is compromised in multiple myeloma patients [6,9,10]. Indeed, patients with myeloma have a high risk of infection due to an impairment of specific humoral immunity.…”

Section: Discussionmentioning

confidence: 99%

“…It incidence increases rapidly with age, and men are more often affected than women [4], [5]. It is most often discovered during an assessment of bone pain, anemia, renal failure or hypercalcemia, and rarely (10%) after an infectious bacterial episode [4,6,7]. Acute otitis media most commonly results from a tubal reaction following nasopharyngeal infection [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…It is rare in adults [8]. The immune deficiency as in multiple myeloma is a favorable factor [2,6,8]. This immunosuppression in multiple myeloma is the result of an inhibition of the production of normal immunoglobulins and an increase susceptibility to infections [4].…”

Section: Introductionmentioning

confidence: 99%

“…This immunosuppression in multiple myeloma is the result of an inhibition of the production of normal immunoglobulins and an increase susceptibility to infections [4]. The sensitivity is increased to infections linked to encapsulated germs, such as Streptococcus pneumoniae and Haemophilus influenzae, induced by the accumulation of malignant plasma cells in the bone marrow [2,6]. The prognosis varies from patient to patient from a few months to several years.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Multiple Myeloma Revealed by a Acute Otitis Media in Adults

Samaké¹,

Youssouf²,

Samaké³

et al. 2020

IJO

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Multiple myeloma or Kahler's disease is a malignant hemopathy characterized by a clonal proliferation of tumor plasma cells that invade the hematopoietic bone marrow. It is often discovered preferentially during spine, pelvis and ribs pain. Kahler's disease are rarely discovered during ENT infections. We report a case of a 58-year-old female patient that we exanimated in our ENT service for acute suppurative otitis media. The remainder of the examination revealed a swelling in the breast and functional impairment of the right upper limb. The maxillofacial CT-scan revealed lytic lacunar images of maxilla and cranial vault. Conventional X-ray displayed a fracture of the right humeral shaft. The positive diagnosis of multiple myeloma was made using bone marrow biopsy that has shown the presence of pathological plasmatic cells proliferation. Furthermore examination such as the plasma protein electrophoresis found hypo-gamma-globulinemia. Analysis of urinary sediment found κ-like Bence-Jones proteinuria. We provided Biphosphonates and analgesics treatment in addition to that of acute otitis media. Unfortunately, the death occurred six months later before he was able to benefit from a more invasive treatment protocol. This observation shows us that acute otitis media should not be trivialized, as it required a rigorous clinical examination and may surprise us.

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Section: Discussionmentioning

confidence: 63%