Artesunate promotes osteoblast differentiation through miR-34a/DKK1 axis

Zeng, Hanbing; Dong, Liqiang; Xu, Chao; Xiao-yan, Zhao; Wu, Lianguo

doi:10.1016/j.acthis.2020.151601

Cited by 19 publications

(21 citation statements)

References 26 publications

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“…Likewise, DKK1 was identified as a direct target of miR-372 and miR-373 in breast cancer and CRC cells, and knockdown of DKK1 promoted the growth and invasive activity of cancer cells ( Zhou et al, 2012 ). Many other miRNAs, in addition to the ones mentioned above, have been identified as related to DKK1, including miR-9, miR-31, miR-33a-5p, miR-34a, miR-92b, miR-101, miR-103a-3p, miR-130b-3p, miR-152, miR-291a-3p, miR-302b, miR-373-3p, miR-410, miR-433-3p, miR-488, miR-493, miR-501-5p, miR-522, miR-523-3p, miR-543, miR-590-3p, miR-613, miR-3064-3p, and miR-BART10-3p ( Liu et al, 2016b ; Fan et al, 2016 ; Jia et al, 2016 ; Zhang et al, 2016 ; Feng et al, 2017 ; Lv et al, 2017 ; Tang et al, 2017 ; Weng et al, 2017 ; Wang et al, 2018a ; Wang et al, 2018b ; Chen et al, 2018 ; Zhao et al, 2018 ; Liu et al, 2019 ; Min and Lee, 2019 ; Wang et al, 2019 ; Li et al, 2020a ; Li et al, 2020b ; Liu et al, 2020 ; Xiang et al, 2020 ; Zeng et al, 2020 ; Zhou et al, 2020 ; Liao et al, 2021 ; Song et al, 2021 ; Wu et al, 2021 ).…”

Section: Dkk1 Inhibitorsmentioning

confidence: 99%

Drug Discovery of DKK1 Inhibitors

Jiang

Yu²,

Chu

et al. 2022

Front. Pharmacol.

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Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin signaling pathway, whose dysregulation is associated with multiple abnormal pathologies including osteoporosis, Alzheimer’s disease, diabetes, and various cancers. The Wnt signaling pathway has fundamental roles in cell fate determination, cell proliferation, and survival; thus, its mis-regulation can lead to disease. Although DKK1 is involved in other signaling pathways, including the β-catenin-independent Wnt pathway and the DKK1/CKAP4 pathway, the inhibition of DKK1 to propagate Wnt/β-catenin signals has been validated as an effective way to treat related diseases. In fact, strategies for developing DKK1 inhibitors have produced encouraging clinical results in different pathological models, and many publications provide detailed information about these inhibitors, which include small molecules, antibodies, and nucleic acids, and may function at the protein or mRNA level. However, no systematic review has yet provided an overview of the various aspects of their development and prospects. Therefore, we review the DKK1 inhibitors currently available or under study and provide an outlook on future studies involving DKK1 and drug discovery.

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Section: Dkk1 Inhibitorsmentioning

confidence: 99%

Drug Discovery of DKK1 Inhibitors

Jiang

Yu²,

Chu

et al. 2022

Front. Pharmacol.

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“…Treating hBMSCs with 2.5–10 μM ART increased alkaline phosphatase (ALP) activity, Alizarin Red S (ARS) staining, and the mRNA and protein expression of osteocalcin (OCN), Runx2, and osteopontin (OPN), suggesting the ability of ART in promoting osteogenesis. ART treatment activated the Wnt pathway by downregulating DKK1 and upregulating β-catenin, cyclin D1, and c-myc, but overexpression of DKK1 proved to inhibit ART osteogenesis promotion [ 95 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

“…Bioinformatics studies showed the existence of a direct binding site between DKK1 and miR-34a mimic. Thus, ART can promote osteoblast differentiation through the miR-34a/DKK1/Wnt pathway [ 95 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

Recent Advances in the Therapeutic Efficacy of Artesunate

2022

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Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

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“…Artesunate (ART) is a derivative of artemisinin, which has anti‐viral, anti‐tumour and anti‐malaria functions. Zeng et al 113 observed that 2.5–10 μM ART inhibited the expression of DKK1 in hBMSCs and increased the protein levels of cyclin D1, β‐catenin and c‐myc in a dose‐dependent manner, thereby promoting the process of osteogenic differentiation. Zeng et al 114 proved that 12.5 μM ART inhibited the activation of PLCγ1 and the increase of Ca 2+ level induced by LPS in RAW264.7 cells, and also reduced the protein expression of the catalytic subunit of CaN.…”

Section: Diverse Ca 2+ /Can/nfat Signalling Pathway Modulating Compounds Which Regulate Osteogenic Differentiationmentioning

confidence: 99%

The role of Ca²⁺/Calcineurin/NFAT signalling pathway in osteoblastogenesis

et al. 2021

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The bone remodelling process is closely related to bone health. Osteoblasts and osteoclasts participate in the bone remodelling process under the regulation of various factors inside and outside. Excessive activation of osteoclasts or lack of function of osteoblasts will cause occurrence and development of multiple bone‐related diseases. Ca2+/Calcineurin/NFAT signalling pathway regulates the growth and development of many types of cells, such as cardiomyocyte differentiation, angiogenesis, chondrogenesis, myogenesis, bone development and regeneration, etc. Some evidences indicate that this signalling pathway plays an extremely important role in bone formation and bone pathophysiologic changes. This review discusses the role of Ca2+/Calcineurin/NFAT signalling pathway in the process of osteogenic differentiation, as well as the influence of regulating each component in this signalling pathway on the differentiation and function of osteoblasts, whereby the relationship between Ca2+/Calcineurin/NFAT signalling pathway and osteoblastogenesis could be deeper understood.

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Artesunate promotes osteoblast differentiation through miR-34a/DKK1 axis

Cited by 19 publications

References 26 publications

Drug Discovery of DKK1 Inhibitors

Drug Discovery of DKK1 Inhibitors

Recent Advances in the Therapeutic Efficacy of Artesunate

The role of Ca²⁺/Calcineurin/NFAT signalling pathway in osteoblastogenesis

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Artesunate promotes osteoblast differentiation through miR-34a/DKK1 axis

Cited by 19 publications

References 26 publications

Drug Discovery of DKK1 Inhibitors

Drug Discovery of DKK1 Inhibitors

Recent Advances in the Therapeutic Efficacy of Artesunate

The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis

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Product

Resources

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The role of Ca²⁺/Calcineurin/NFAT signalling pathway in osteoblastogenesis