Artesunate attenuates 2, 4-dinitrochlorobenzene-induced atopic dermatitis by down-regulating Th17 cell responses in BALB/c mice

Bai, Xinyu; Liu, Ping; Chai, Yeewen; Wang, Yan; Ren, Shuang-Hua; Li, Yingying; Zhou, Hong

doi:10.1016/j.ejphar.2020.173020

Cited by 35 publications

(25 citation statements)

References 39 publications

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“…At high doses, dihydroartemisinin significantly alleviated mast cell infiltration into the skin lesions ( 30 ), indicating that it exerts therapeutic effects on AD by targeting mast cells in the skin. Similarly, artesunate relieved AD symptoms and mast cell infiltration, mainly by decreasing the expression of proinflammatory cytokines, including IL-6, IL-17 and IL-23, and suppressing RORγt and STAT3 phosphorylation ( 31 ). Taken together, these studies have indicated that ARTs attenuate both psoriasis and AD through inhibition of CD8+ memory T cells, Th17/γδ T cells and mast cells.…”

Section: Immune-mediated Skin Diseases: Psoriasis and Atopic Dermatitismentioning

confidence: 99%

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Qiu

Liu

et al. 2021

Front. Immunol.

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Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and Medicine due to her discovery of artemisinin and its therapeutic effects on malaria. Apart from antimalarial effects, mounting evidence has demonstrated that ARTs exert therapeutic effects on inflammation and autoimmune disorders because of their anti-inflammatory and immunoregulatory properties. In this aspect, tremendous progress has been made during the past five to seven years. Therefore, the present review summarizes recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection. In this review, we also discuss the cellular and molecular mechanisms underlying the immunomodulatory effects of ARTs. Recent preclinical studies will help lay the groundwork for clinical trials using ARTs to treat various immune-based disorders, especially autoimmune diseases.

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Section: Immune-mediated Skin Diseases: Psoriasis and Atopic Dermatitismentioning

confidence: 99%

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Qiu

Liu

et al. 2021

Front. Immunol.

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“…In other studies, expression of IL-6 and SERPINA1 was increased with disease progression [35] , [36] . SOCS3 expression has been shown to be negatively correlated with IL-6 expression [37] , [38] , [39] , [40] . A negative correlation between expression of TPCN1 and TOMM20 and IL-6 expression has been documented [40] , [41] .…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of transcriptome datasets: An alternative method to study IL-6 regulation in coronavirus disease 2019

Liu¹,

Lin²,

Ao³

et al. 2021

Computational and Structural Biotechnology Journal

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“…erefore, finding novel natural chemicals from medicinal plants with fewer side effects should be performed to treat AD [34]. Various immune regulators from natural herbal extracts could have therapeutic potentials for AD [11][12][13]. Ethnopharmacologic studies on Radix Salviae suggest beneficial effects including anti-inflammation, antioxidant activity, and immune regulation.…”

Section: Discussionmentioning

confidence: 99%

“…Human AD-like skin lesions are induced by several animal models including models induced by epicutaneous exposure to sensitizers [10]. A cytotoxic and electrophilic benzene derivative, 2,4-dinitrochlorobenzene (DNCB), was reported to induce stable clinical AD-like skin diseases in BALB/c mice [11][12][13]. Histological studies have shown hyperplasia and mast cells accumulation in the skin [10,14].…”

Section: Introductionmentioning

confidence: 99%

Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

Jeon

Lee

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Prevalence of atopic dermatitis (AD), a chronic, pruritic, and relapsing inflammatory skin disorder, is growing. Because available therapeutics is limited, immune regulators from natural resources could be helpful for treating AD symptoms. The root of Salvia miltiorrhiza Bunge (Lamiaceae) has been studied for the treatment of inflammatory diseases, including dermatologic disorders in Korea. This study examined the effect of salvianolic acid A on AD-like symptoms. Sensitization on the dorsal skin and repeated application on the ears with 2,4-dinitrochlorobenzene (DNCB) were performed in BALB/c mice to induce AD-like skin lesions. After induction of atopic dermatitis, salvianolic acid A (5 and 10 mg/kg) or dexamethasone (10 mg/kg) were administrated via intraperitoneal injection for 3 weeks. Salvianolic acid A suppressed DNCB-induced AD-like symptoms like ear skin hypertrophy and decreased mast cell infiltration into skin lesions. Salvianolic acid A not only reduced DNCB-induced increase of serum IgE but also lowered levels of the Th2 cytokines (IL-4 and IL-13), Th1 cytokine (interferon-γ), and Th17 cytokine (IL-17A). Furthermore, salvianolic acid A blocked DNCB-induced lymph node enlargement. In summary, these results suggest that salvianolic acid A might have a therapeutic potential for the treatment of AD.

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Artesunate attenuates 2, 4-dinitrochlorobenzene-induced atopic dermatitis by down-regulating Th17 cell responses in BALB/c mice

Cited by 35 publications

References 39 publications

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Meta-analysis of transcriptome datasets: An alternative method to study IL-6 regulation in coronavirus disease 2019

Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

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